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首页> 中文期刊> 《实用临床医药杂志》 >吸入麻醉药七氟醚对儿童学习记忆的影响

吸入麻醉药七氟醚对儿童学习记忆的影响

         
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摘要

目的 观察研究吸入麻醉药七氟醚对儿童高级神经活动学习、记忆功能的影响.方法 选择7～10岁男生择期下腹部手术33例,分为七氟醚组(20例)和对照组(13例).采用“韦氏记忆量表”进行学习记忆能力的测试,测试术前、术后1d、术后1周长时记忆、短时记忆及瞬时记忆的量表得分.结果 ①七氟醚组和对照组2组术后1d与术前、术后1周相比,短时记忆量表得分均显著下降,差异有显著性(P＜0.05)；②术后1周2组患儿的短时记忆量表得分均已经接近原来的水平；③术后1d短时记忆量表得分七氟醚组与对照组量表得分相近,差异没有显著性意义.结论 ①手术患儿学习记忆能力的改变,术后1d在短时记忆的分测验中有明显的下降,而对长时记忆和瞬时记忆没有明显改变；②未能提示吸入麻醉药七氟醚对儿童学习记忆能力的影响是一个独立的风险因素.%Objective To investigate the possible effects of general anesthesia with sevoflu-rane on learning and memory of children. Methods The ability of learning and memory was evaluated with Wechsler Memory Scale before operation, one day and seven days after operation. Thirty three boys aged 7-10 years old undergoing elective hypogastric surgery were enrolled, of which 20 cases were treated with sevoflurane and 13 were put in control group. The long - term, short - term and instantaneous memory were measured. Results ① Comparing results one day after operation to results before operation and seven days after operation, short - term memory scale scores decreased significantly in both sevoflurane and control groups one day after operation, and the difference was significant (P<0. 05); ② The short - term memory scale scores of both two groups of children were close to the original level one week after operation. ? One day after operation the short- term memory scale scores of sevoflurane group and control group were similar, and the difference was not statistically significant. Conclusion ① For the changes of learning and memory a-bility in children going through operations, one day after operation scores in the short - term memory sub - tests have dropped significantly, while long - term memory and instantaneous memory scores did not change significantly. ② It is an independent risky factor not to point out the impact of inhaling anesthetic sevoflurane to learning and memory ability of children.

著录项

  • 来源
    《实用临床医药杂志》 |2011年第23期|24-2528|共3页
  • 作者

    朱贵芹; 朱霞; 郑闽江; 王丽华; 李加凯; 邱燕林; 杨爱兴; 张文明; 李小民;

  • 作者单位

    江苏省连云港市第一人民医院东方医院麻醉科,江苏连云港,222042;

    江苏省连云港市第一人民医院东方医院麻醉科,江苏连云港,222042;

    江苏省连云港市第一人民医院东方医院麻醉科,江苏连云港,222042;

    江苏省赣榆县人民医院手术室,江苏赣榆,222100;

    江苏省连云港市第一人民医院东方医院麻醉科,江苏连云港,222042;

    江苏省连云港市第一人民医院东方医院麻醉科,江苏连云港,222042;

    江苏省连云港市第一人民医院东方医院麻醉科,江苏连云港,222042;

    江苏省连云港市第一人民医院东方医院麻醉科,江苏连云港,222042;

    江苏省连云港市第一人民医院急诊科,江苏连云港,222000;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 麻醉学原理;
  • 关键词

    七氟醚; 儿童; 学习; 记忆;

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