Objective To investigate the relationship between arterial stiffness and white matter lesions ( WMLs) in patients with acute cerebral ischemic stroke.Methods The clinical data of 105 patients with acute cerebral ischemic stroke were collected.The MRI examination and the arterial stiffness were detected.The brachial ankle pulse wave velocity ( baPWV) and the ankle-brachial index ( ABI) were measured.The severity of WMLs was judged by Fazekas scores and the patients were divided into no or mild WMLs group and severe WMLs group.The results were analyzed.Results In the 105 patients, there were 63 cases in no or mild WMLs group (60%) and 42 cases in severe WMLs group (40%) .The rate of hypertension and the age, systolic blood pressure, diastolic blood pressure in severe WMLs group were significantly higher than those in no or mild WMLs group (P<0.05-0.01). The baPWV in severe WMLs group [(2002 ±340) cm/s] was significantly higher than that in no or mild WMLs group [(1826 ±328)cm/s](P=0.004).The difference of ABI between the two groups was no statistical signifi-cance (P=0.84).Multiple Logistic regression analysis showed that age (OR=1.06, 95%CI:1.01-1.12, P=0.021) and baPWV (OR=1.32, 95%CI:1.07-1.55, P=0.002) were the independent risk factors for severe WMLs in patients with acute cerebral ischemic stroke.Conclusion The arterial stiffness in patients with acute cerebral ischemic stroke is closely related with WMLs, and the baPWV is the independent risk factor for severe WMLs.%目的：探讨急性缺血性脑卒中患者血管僵硬度与脑白质病变（ WMLs ）的关系。方法采集105例急性缺血性脑卒中患者的临床资料。对患者进行头颅MRI及血管僵硬度检查，测定双侧踝－臂脉搏波传导速度（baPWV）及踝－肱指数（ABI）等。采用 Fazekas 量表评分判断WMLs 严重程度并分为无或轻度WMLs组和重度WMLs组。对结果进行分析。结果本组105例患者中，无或轻度WMLs组63例（60％）、重度WMLs组42例（40％）。重度WMLs组高血压病的比例和年龄、收缩压、舒张压均明显高于无或轻度WMLs组（P＜0．05～0．01）。重度WMLs组baPWV[（2002±340）cm／s]明显高于无或轻度WMLs组[（1826±328） cm／s]（P＝0．004）。两组ABI比较差异无统计学意义（P＝0．84）。多因素Logistic回归分析显示，年龄（OR＝1．06，95％CI：1．01～1．12，P＝0．021）和baPWV（OR＝1．32，95％CI：1．07～1．55，P＝0．002）是急性缺血性脑卒中患者发生重度WMLs的独立危险因素。结论急性缺血性脑卒中患者血管僵硬度与WMLs密切相关，且baPWV是其伴发重度WMLs的独立危险因素。
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