Objective To explore the influence of life quality after treated with botulinum toxin type A (BTXA) local injection in patients with hemifacial spasm (HFS).Methods One hundred and eight HFS patients were treated with BTXA local injection.The spasm degree and curative effect were evaluation by Cohen classification standard before and 3 and 6 months after treatment; meanwhile the quality of life scale (QOL-BREF),self-rating depressive scale (SDS) and self-rating anxious scale (SAS) were scored.Results At 3 and 6 months after treatment,the degree of Cohen classification were decreased significantly than before treatment; the marked efficient rate and total effective rate were 90.1％,100％ at 3 months after treatment,and 83.3％,96.3％ at 6 months after treatment.Compared with before treatment,each score of QOL-BREF except the enviroment score was significantly increased,and the scores of SDS,SAS were significantly decreased (all P ＜ 0.05).The rates of the patients with depressive and anxious were decreased significantly (all P ＜ 0.05).Conclusion BTXA treated on HFS is effective,and can obviously improve health-related quality of life.%目的 探讨A型肉毒毒素(BTXA)局部注射治疗对偏侧面肌痉挛(HFS)患者生活质量的影响.方法 给予108例HFS患者BTXA局部肌肉注射治疗.在治疗前、治疗后3及6个月时应用Cohen分级标准进行痉挛程度及疗效评价,用生活质量量表(QOL-BREF)、抑郁自评量表(SDS)、焦虑自评量表(SAS)进行测评.结果 治疗后3及6个月时Cohen分级较治疗前明显下降；治疗3个月时显效率及总有效率为90.1％、100％,6个月时为83.3％、96.3％.与治疗前比较,治疗3及6个月时除环境评分外,各项QOL-BREF量表评分明显提高,SDS及SAS评分明显降低(均P＜0.05)；有抑郁及焦虑情绪的比率明显降低(均P＜0.05).结论 BTXA治疗HFS疗效显著,并能明显改善其健康相关生存质量.
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