Objective To approach the application value of event-related potentials N400 on evaluating language function in stroke patients. Methods The language function of 20 patients with single brain lesion and first episode stroke (stroke group) and 20 controls without brain injury (control group) were evaluated, and the N400 was detected. The results were analyzed. Results The disturbance rate of writing was 35% in stroke group, while there was no disturbance of writing in control group. The scores of oral expression, hearing comprehension, repeating, naming and reading in the stroke group were all significantly lower than that in control group (all P <0. 05 -0.01). The scores of cloze test of reading in stroke group (83.0 ±24.32) was significantly lower than that in control group (98.33 ±7.45 ) (P <0. 001). The latency of N400 all the sites in stroke group were significantly longer than control group, and the amplitude of Pz, T4 sites were significantly lower than control group (all P<0.05). In the stroke group, the latency of N400 T4 site was significantly longer, and the amplitude was significantly lower than Fz site (all P < 0. 05) j the amplitude of T3, T4 sites were significantly lower than Pz site ( all P < 0.05). In the control group, there was no significant difference of latency among all the sites; the amplitude of Pz site was significantly higher than Fz, T3, T4 sites (all P < 0. 05). Spearman analysis showed that there was no correlation between the " sentence-word" of N400 and the score of "cloze test" of reading function of the stroke patients. Conclusions The right tempus maybe participate in the cognition processing of semantics. It is consistent of N400 and language function detection, and the N400 can be used to evaluate the language function of stroke patients.%目的 探讨事件相关电位N400在脑卒中患者语言功能评估中的应用价值.方法 对20例首发单病灶脑卒中患者(脑卒中组)和20名无脑损害的对照者(对照组)进行语言功能检查和N400检查,并对结果进行分析.结果 脑卒中组书写障碍的发生率为35％,而对照组无书写障碍发生.脑卒中组口语表达、听理解、复述、命名、阅读各项得分均明显低于对照组(P＜0.05～0.01).脑卒中组选词填空得分[(83.0±24.32)分]明显低于对照组[(98.33±7.45)分](P＜0.001).脑卒中组N400各点潜伏期均较对照组明显延长,Pz、T4点波幅均较对照组明显降低(均P＜0.05).脑卒中组中,N400 T4点潜伏期较Fz点明显延长,波幅较Fz点明显降低(均P＜0.05)；T3、T4点波幅较Pz点明显降低(均P＜0.05).对照组中,N400各点潜伏期差异无统计学意义；Pz点波幅均显著高于Fz、T3、T4点(均P＜0.05).Spearman相关分析示,脑卒中患者“句子-词语”N400与阅读功能检查中“选词填空”项得分间无相关性.结论 右颞可能参与语义的认知加工.N400与语言功能检查具有一致性,可以将N400运用于临床脑卒中患者语言功能的评估.
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