Objective To investigate the effect of bushen huoxue recipe on bone density and the biochemical index of bone metabolism in senile osteoporosis.Methods The 92 cases of senile osteoporosis were randomly divided into control group(46 cases) and research group (46 cases) according to different treatment plans.The patients in the control group received 200 IU salmon calcitonin nasal spray,once every two days,treatment of 6 months.The patients in research group were administered with bushen huoxue recipe on the basis of control group.After treatment of 6 months,the indexes of Ca2+,P,BALP,BGP,TRAP-Sb,β-CTX in blood serum and bone mineral density were determined before and after the treatment.Results After 6 months of treatment,bone density of the femoral neck,L2-4 and Ward's region in the research group were significantly higher than those before treatment and control group (P ＜ 0.05),while there were no significant differences in the control group,compared with the preoperation (P ＞ 0.05).There were no significant differences in the contents of blood calcium and phosphorus between the two groups at 6 months after treatment (P ＞ 0.05),and there were no differences between the preoperation and 6 months postoperation(P ＞ 0.05).After 6 months of treatment,in the research group,the levels of BALP and BGP were increased,and the levels of TRAP-Sb and β-CTX were decreased,which were superior to before treatment and control group (P ＜0.05),while the differences in the control group were not statistically significant for the four items(P ＞ 0.05).Conclusions Bushen huoxue recipe can improve the bone density in elderly patients with osteoporosis by enhancing bone formation and inhibiting bone resorption,which have a good clinical efficacy.%目的 探讨补肾活血方对老年骨质疏松症患者骨密度及相关骨代谢生化指标的影响.方法 将92例骨质疏松症患者随机分为对照组和研究组,每组46例.对照组以鲑鱼降钙素200 IU喷鼻,隔天1次,治疗6个月;研究组在对照组的基础上口服中药补肾活血方,3天1剂,治疗6个月.治疗6个月后,观察并检测骨质疏松症患者人体骨密度、血清钙、血清磷、骨源性碱性磷酸酶(BALP)、血清骨钙素(BGP)、Ⅰ型胶原羧基端肽β特殊序列(β-CTX)和人抗酒石酸酸性磷酸酶5b(TRAP-5b)的含量变化.结果 治疗6个月后,研究组腰椎L2～4、股骨颈、Ward区的骨密度均较治疗前提高(P＜0.05),且均明显高于对照组(P＜0.05);而对照组各项骨密度与治疗前比较差异无统计学意义(P＞0.05).治疗6个月后,两组血清钙、磷的含量比较,以及与治疗前比较差异均无统计学意义(P＞0.05).治疗6个月后,研究组BALP、BGP含量均升高,TRAP-5b、β-CTX含量均降低,与治疗前比较差异均有统计学意义(P＜0.05),且各项指标均优于对照组(P＜0.05);而对照组4项指标与治疗前比较差异均无统计学意义(P＞0.05).结论 补肾活血方可以通过促进骨形成、抑制骨吸收来提高骨质疏松症患者骨密度,从而达到治疗老年骨质疏松症的疗效.
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