Objective To develop an anatomically accurate finite element model of knee joint through the method of multimodality CT and MRI image data fusion and to further analyze and verify it for offering a useful tool for the study of knee biomechanics. Methods CT and MRI image data of an intact knee joint were imported into Mimics soft-ware. 3D models of bones,articular cartilages and ligaments were respectively constructed from image data. Following the fusion of the constructed 3D models based on external landmarks, the complete knee model was constructed. Then the knee finite element model was developed in Hypermesh software. Based on anatomical observation and manual measurement, the finite element model was assessed in its fidelity level. Finally the finite element model was analyzed and verified after the definition of its material behavior, boundary conditions and loading. Results The complete knee finite element mode composed of bone,meniscus, articular cartilage,and ligament was developed from CT and MRI images, and it maintained its important anatomical features of knee joint. The obtained finite element analysis results corresponded to that reported in the literature, which meaned the model′s reliability. Conclusions Through the method of multimodality CT and MRI image data fusion, the anatomically accurate finite element model of knee joint can be developed, and it maintains its important anatomical features. This model is a useful tool for the study of knee biomechanics.%目的 通过多模态CT和MRI影像数据融合构建膝关节有限元解剖模型,并进行有限元分析和验证,为膝关节力学仿真研究提供可靠的有限元模型. 方法 采集正常膝关节CT和MRI影像数据,导入到 Mimics软件中,构建膝关节骨骼、半月板、关节软骨、韧带等结构的三维模型. 以外部标记为参照点进行模型配准,融合成膝关节整体模型. 在Hypermesh软件中进行网格划分,构建膝关节有限元模型. 通过解剖观察和测量对有限元模型进行解剖真实度评估,对其设置材料属性、建立边界条件和施加载荷,进行有限元分析,并验证.结果 基于CT和MRI影像数据构建出包含骨骼、半月板、关节软骨、韧带等多种组织结构的膝关节有限元整体模型,模型保持了膝关节的解剖学特征,有限元分析结果与文献报道的结果一致,显示有限元模型可靠、有效. 结论 通过多模态CT和MRI影像数据融合可以构建符合解剖学特征的膝关节有限元整体模型,能为研究膝关节生物力学行为提供可靠、有效的有限元模型.
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