目的 探讨3 个哮喘易感基因单核苷酸多态性(SNPs)位点与哮喘预测指数(API)阳性婴幼儿喘息的相关性.方法将201 例喘息婴幼儿分为API 阳性组(68 例)和API 阴性组(133 例).选取儿童哮喘易感基因SNPs 位点ADRβ2R16G、FcεR1 E237G 和IL13 A2044G,采用TaqMan 探针法对两组患儿进行基因分型,分别比较上述基因多态性位点在阳性组和阴性组间的分布差异.结果 多态性位点FcεR1 E237G AG 杂合子在API 阳性组的频率明显高于阴性组( 分别为41.2% 和24.1%),差异有统计学意义(χ2=6.30,P=0.012,OR=2.21,95% CI=1.18～4.13),而ADRβ2 R16G 和IL13 A2044G 位点在两组间的分布差异无统计学意义(χ2=1.72、1.85,P 均＞ 0.3).结论 儿童哮喘易感基因单核苷酸多态性FcεR1 E237G AG杂合子与API 阳性患儿喘息相关,未发现ADRβ2 R16G 和IL13 A2044G 多态性与API 阳性患儿喘息相关.%Objectives To investigate the correlation of three single nucleotide polymorphisms (SNPs) in asthma susceptibility genes with asthma predicting index (API) positive infantile wheezing. Methods Two hundreds and one wheezing infants were recruited and divided into two groups, API positive (n=68) or negative (n=133) groups. TaqMan probe was applied to detect the genotypes of three SNPs in childhood asthma susceptibility genes. They were ADRβ2 R16G, FcεR1 E237G and IL13 A2044G. The genotype distributions were analyzed and compared between the two groups. Results The frequency of FcεR1 E237G AG heterozygote in the API positive group was significantly higher than that in the negative group (x2=6.30, P=0.012, OR=2.21, 95%CI=1.18~4.13), while no significant differences were found in the genotype distribution of ADRβ2R16G and IL13A2044G between the two groups (x2=1.72,1.85 respectively; P>0.3). Conclusions Childhood asthma susceptibility SNP FcεR1 E237G AG heterozygote is related to API positive infantile wheezing. ADRβ2 R16G and IL13 A2044G polymorphisms are not found associated with API positive infantile wheezing in the present study.
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