Objective:To explore the serum level of homocysteine(Hcy)and blood lipid in deficit and non-deficit schizophrenia patients and the relationship between them. Method:Used enzymatic assay to test the serum levels of Hcy and blood lipid and the positive and negative syndrome scale(PANSS)were used to e-valuate the psychiatric symptoms,58 deficit schizophrenia patients(DS)and 60 non-deficit schizophrenia pa-tients(NDS)with acute onset were detected on the second day after admission,the Hcy and blood lipid levels in 64 normal controls(NC)were detected by the same method,and the differences between the three groups were compared. Results:The levels of Hcy and total cholesterol(TC)and high density lipid-cholesterol(HDL-C) in NC were higher than that in the two patient groups(P<0.05).There was no significant difference between the DS and NDS patients(P>0.05).The scores of negative symptoms in DS were higher than those in NDS (t=24.840,P<0.001),the scores of positive symptoms in NDS were higher than those in DS,there were no significant difference between DS and NDS on the total score(t=0.275,P=0.784)and the score of general psychopathology factors(t=1.005,P=0.317).The Hcy level in the three groups were related to gender,the Hcy level in males was higher than that in females,DS(t=3.146,P=0.003),NDS(t=2.624,P=0.011), NC(t=4.753,P<0.001).The level of HDL-C in the female patients was higher than that of males in the DS (t=2.711,P=0.009)and NDS(t=3.220,P=0.002).There were no significent differences between males and females in blood lipid indexes in NC(P<0.05). Conclusion:In young adults,the Hcy and lipid levels in schizophrenia are not higher than NC and there is no difference between DS and NDS.Hcy levels patients are higher in male than female,and the HDL-C levels are higher in female than male.Hcy in DS is associated with negative symptoms.%目的:研究缺陷型与非缺陷型精神分裂症患者同型半胱氨酸(Hcy)、血脂水平及其相关性.方法:于入院次日对58例住院缺陷型精神分裂症患者(DS)、60例非缺陷型精神分裂症患者(NDS)采用酶法检测血清Hcy、血脂水平,以阳性和阴性症状量表(PANSS)评估患者精神症状.采用同样方法检测64名对照者的Hcy、血脂水平,并比较三组间差异. 结果:对照组Hcy、总胆固醇(TC)、高密度脂蛋白(HDL-C)水平均高于两患者组(P<0.05),缺陷型与非缺陷型患者比较无统计学差异(P>0.05);缺陷型PANSS阴性因子分高于非缺陷型(t=24.840,P<0.001),非缺陷型PANSS阳性因子分高于缺陷型(t=29.918,P<0.001),PANSS总分(t=0.275,P=0.784)、PANSS一般精神病理分(t=1.005,P=0.317)两组比较差异无统计学意义;三组Hcy水平均与性别相关,即男性高于女性,缺陷型(t=3.146, P=0.003),非缺陷型(t=2.624,P=0.011),对照组(t=4.753,P<0.001);缺陷型、非缺陷型患者HDL-C女性均高于男性(t=2.711,P=0.009;t=3.220,P=0.002);对照组血脂各项指标男女无统计学差异(P<0.05). 结论:在青壮年,精神分裂症患者Hcy和血脂水平并没有高于正常人群;缺陷型与非缺陷型患者Hcy和血脂水平无差异,但男性患者Hcy高于女性,而女性HDL-C高于男性,且缺陷型患者Hcy与阴性症状相关.
展开▼
