目的：利用静息态功能磁共振，结合局部一致性分析方法探讨临床治愈的抑郁患者局部脑功能的改变。方法：对19例临床治愈的抑郁症患者（患者组）和14名健康志愿者（正常对照组）进行功能磁共振扫描，通过双样本t检验比较两组被试者脑区局部一致性。结果：与正常对照组比较，患者组左背内侧前额叶（t=4.070，P<0.01）、左梭状回（t=3.855，P<0.01）局部一致性增高；左颞中回（t=-4.851，P<0.01）、左顶下小叶（t=-4.459，P<0.01）及右楔叶（t=-3.477，P<0.01）局部一致性降低。结论：临床治愈的抑郁症患者存在部分脑区的功能异常。%Objective:To explore regional brain functional changes of remitted depression using a resting-state functional magnetic resonance imaging( fMRI)and regional homogeneity( ReHo). Method:Nineteen patients with remitted depression( patients group)and 14 well-matched heathly controls( controls group)un-derwent fMRI scan. Two-sample t-test was used to compare ReHo between patients group and controls group. Resuits:Compared with the controls,the remitted depression patients showed increased ReHo in the left medial superior frontal gyrus(t=4. 070,P<0. 01)and fusiform gyrus(t=3. 855,P<0. 01),and decreased ReHo in the left middle temporal gyrus(t= -4. 851,P<0. 01),left inferior parietal lobule(t= -4. 459,P<0. 01)and right cuneus(t= -3. 477,P<0. 01). Conciusion:The remitted depression is associated with abnormal func-tioning of certain brain regions.
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