The brain derived neurotrophic factor (BDNF) hypothesis of depres‐sion thinks that BDNF function loss participates in the pathophysiological process of depression ,and the effective treatment of antidepressants could restore function .This hypothesis is based on the discovery that BDNF concentration reduction in patients with major depression and healthy persons with depression per‐sonality characteristics and BDNF levels again heighten after antidepressant treatment .%抑郁症的脑源性神经营养因子假说认为，脑源性神经营养因子的功能丧失参与了抑郁症的病理生理过程，而抗抑郁药的有效治疗可以恢复其功能。这一假说是基于在重症抑郁患者和具有抑郁相关人格特征的健康人中脑源性神经营养因子的浓度降低，而经抗抑郁药治疗以后脑源性神经营养因子水平又升高这一发现提出来的。
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