目的：了解马鞍山市结核病耐药流行情况及影响因素，为耐药结核病的预防和控制提供依据。方法按照全国结核病耐药性监测实施方案要求，对马鞍山市2013年所有新登记的肺结核患者进行痰培养，并对培养阳性菌株进行菌种鉴定和一、二线抗结核药物敏感试验。结果2013年新登记肺结核患者481人，培阳并可纳入耐药分析127人，总耐药率和耐多药率分别为37．80%和9．45%，其中初始总耐药率和耐多药率为32．00%和5．00%，获得性总耐药率和耐多药率为59．26%和25．93%。结论马鞍山市结核病耐药疫情较为严峻，今后需进一步加强耐药结核病的防治工作。%Objective To understand the epidemic situation and impact factors of drug-resistant tuberculosis in Maanshan City, in order to provide evidence for developing strategies on control and prevention of drug-resistant tu-berculosis. Methods According to the guidelines of national tuberculosis drug-resistance surveillance project, the sputum samples of the tuberculosis patients new registered in 2013 in Maanshan were cultured, and strain identifica-tion and susceptibility tests of the first and second line anti-tuberculosis medicines were performed in all strains. Re-sults A total of 481 TB cases were enrolled in 2013, and 127 patients with positive sputum culture were included in the investigation. The total drug resistance was 37. 80% and the total multi-drug resistance ( MDR) was 9. 45%. The initial drug resistance was 32. 00% and the initial MDR was 5. 00%. The acquired drug resistance was 59. 26% and the acquired MDR was 25. 93%. Conclusion The prevalence of drug-resistant tuberculosis is severe in Maanshan, suggesting the necessary to strengthen the drug-resistance tuberculosis control program.
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