1文献来源rnWolfson AH, Bae K, Komaki R, et al.Primary analysis of a phase Ⅱ randomized trial radiation therapy oncology group (RTOG) 0212:Impact of different total doses and schedules of prophylactic cranial irradiation on chronic neurotoxicity and quality of life for patients with limited-disease small-cell lung cancer [J].Int J Radiat Oncol Biol Phys,2011,81( 1):77-84.2证据水平2a.3背景小细胞肺癌(small cell lung cancer,SCLC)约占肺癌的13％.小细胞肺癌可分为局限期和广泛期,局限期约占30％.尽管放化疗对小细胞肺癌有一定疗效,脑转移仍然是一个重要问题,在长期生存者中发生率约为50％.有研究表明对化疗取得完全缓解的局限期SCLC患者,采用预防性全脑放疗(prophylactic cranial irradiation,PCl)可以改善此类患者的存活率,但是PCI的最佳总量及分割时间尚不完全清楚.
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