目的 用超声法测量角膜厚度,探索其死后变化规律.方法 11只家兔随机分为两组,分别为角膜上皮完整组及去角膜上皮组.后者采用机械刮除法去除角膜上皮.利用超声测厚仪连续监测两组动物的死后多个时间点的角膜厚度,并对角膜厚度变化与死亡时间进行相关回归分析.结果 超声法测量角膜上皮完整组死后兔角膜厚度的变化值与死亡时间呈非线性相关,且具有较强的相关性,相关系数为0.922,而去角膜上皮组的相关系数为0.822.结论 超声法测量角膜厚度对推断早期死亡时间具有较可靠的应用前景.完整的角膜上皮对于超声测量角膜厚度具有关键作用.%Objective To explore the postmortem changes of cornea thickness measured by ultrasonic pachymetry. Methods Eleven rabbits were randomly divided into two groups: one group with intact corneal epithelium and another group without intact corneal epithelium. In the later group, the corneal epithelium of the rabbit was scraped using mechanical elimination method. The corneal thickness was monitored continuously by ultrasonic pachymetry at several postmortem interval points in rabbits of the two groups. The changes of corneal thickness and postmortem interval were explored by relative regression analysis. Results The thickness of the cornea showed a strong non-linear correlation with the postmortem interval in the group with intact corneal epithelium. The group with intact corneal epithelium showed the correlation coefficient 0.922 and the group without intact corneal epithelium showed the correlation coefficient 0.822, respectively. Conclusion The corneal thickness measured by ultrasonic pachymetry shows a potential value for estimating early postmortem interval. The intact corneal epithelium is a crucial factor for the measurement of cornea thickness by ultrasonic pachymetry.
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