目的：探讨帕金森病（PD）患者伴发抑郁与认知功能障碍及运动障碍之间的影响。方法采用汉密尔顿抑郁量表（HAMD）对46例PD患者进行评分，HAMD≥17分为抑郁组，HAMD＜17分为非抑郁组；应用简易精神状态检查（MMSE）、画钟测验（CDT ）、词语流畅性测验（VFT ）、统一PD评价量表（UPDRS）运动分量表评定两组患者的认知功能和运动功能，计算震颤症状得分与运动迟缓症状得分之比，＞0．5者为震颤型组，≤0．5者为强直-少动型组，分析两组的HAMD评分情况，HAMD评分与比值之间的Pearson相关系数。结果抑郁组和非抑郁组之间认知功能评分（MMSE、CDT、VFT 评分）和运动功能评分（运动迟缓评分）差别具有统计学意义（分别为 P＜0．01，P＜0．05，P＜0．01，P＜0．01），而震颤评分无统计学意义（P＞0．05）；强直少动型组 HAMD评分明显高于震颤型组（ P＜0．01），同时 HAMD 评分与震颤评分/运动迟缓评分之比之间存在负相关（r＝-0．523， P＜0．01）。结论PD患者抑郁情绪会加重认知功能障碍及运动功能障碍程度。%Objective To investigate effect of depression on cognitive and movement dysfunction in patients with Parkinson's disease (PD) . Methods 46 patients with PD patients were enrolled and eval-uated by Hamilton depression rating Scale (HAMD) . Patients with scores ≥17 were defined as depres-sion ,and scores <17 as non-depression . Cognitive function and motor function were assessed by Mini-mental state examination (MMSE) ,Clock drawing test (CDT ) ,Verbal fluency test (VFT ) and Unified parkinson’s disease rating scale(UPDRS) subscales . The ratio of the tremor symptoms score/bradykine-sia symptoms score was calculated ,patients with scores >0 .5 were defined as tremor type group ,and those with scores ≤0 .5 as tonic-less acting group . The correlation of HAMD score and the ratio of the tremor symptoms score/bradykinesia symptoms score were analyzed by the Pearson correlation between depression and non-depression groups . Results In PD patients with or without depression ,there was statistically significant differences in cognitive function score (MMSE ,CDT ,VFT score) and motor func-tion score (bradykinesia score) P<0 .05 or P<0 .01 respectively ;however ,there was no significant differ-ence in tremor score . The HAMD score in Tonic less-action group was significantly higher than that in the tremor-type group (P<0 .01) . There was a negative correlation between the HAMD score and the ratio of tremor score /bradykinesia score(r= -0 .523 ,P<0 .01) . Conclusions PD patients with depres-sion have worse cognitive dysfunction and movement dysfunction .
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