首页>
中文期刊>
《老年心脏病学杂志（英文版）》
>Characterization of coronary atherosclerotic plaques in a homozygous familial hypercholesterolemia visualized by optical coherence tomography
Characterization of coronary atherosclerotic plaques in a homozygous familial hypercholesterolemia visualized by optical coherence tomography
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder,which resulted in severe elevations in low-density lipoprotein cholesterol (LDL-C) and a markedly increased risk of early-onset coronary disease.[1] It is most frequently caused by loss-of-function mutations in genes affecting the LDL receptor,which clears LDL particles from plasrna.[2] FH accelerates atherosclerotic cardiovascular disease,especially coronary heart disease,with clinical manifestations often occurring after one to four decades of life.[3] The untreated patients with homozygous familial hypercholesterolemia (HoFH),which is caused by mutations in both alleles of the gene encoding the LDL receptor,developed overt atherosclerosis before the age of 20 years and generally do not survive past 30 years.Intravascular optical coherence tomography (OCT) has been proposed as a high-resolution imaging method for characterization of coronary atherosclerotic plaques.[4] Its utility in the evaluation of plaque composition can provide insights into the pathology of coronary arteries abnormalities.[5] However,little information about coronary atherosclerotic plaques of patients with FH has been presented.
展开▼
机译：The Relation Between Red Blood Cell Distribution Width and Coronary Atherosclerotic Plaque Vulnerability Detected by Intracoronary Optical Coherence Tomography
机译：Development of Tissue Characterization Using Optical Coherence Tomography for Defining Coronary Plaque Morphology and the Vascular Responses After Coronary Stent Implantation
机译：Elevated Levels of systemic pentraxin 3 are associated With Thin-Cap Fibroatheroma in Coronary Culprit Lesions : assessment by Optical Coherence Tomography and Intravascular Ultrasound
