Nicotine is one of the 7000 compounds in tobacco smoke and is the main chemical composition of the smoking addiction .Nicotine and its metabolites can promote tumor grow th through increased prolifera-tion ,migration ,invasion ,epithelial to mesenchymal transition ,angiogenesis ,and stimulation of autocrine loops associated with tumor grow th .Common mechanisms appear to involve activation of nicotinic acetylcho-line receptors and beta -adrenergic receptors leading to dow nstream activation of parallel signal transduction pathways that promote tumor progression and resistance to treatment and reduce the biologic effectiveness of conventional cancer treatments such as chemotherapy and radiotherapy .It show s according to this study that nicotine is an important mechanism by w hich promotes tumor development ,progression ,and resistance to cancer treatment .% 指出了尼古丁是烟草烟雾中的7000多种化合物之一，是吸烟成瘾的主要化学成分。尼古丁及其代谢产物通过促进肿瘤细胞增殖、侵润、上皮细胞间质样转化和血管生成从而促进肿瘤的生长与转移。尼古丁可以与烟碱乙酰胆碱受体和β受体偶联激活下游并行信号转导途径，促进肿瘤形成的进展并对肿瘤治疗产生抗性，降低化疗和放疗等传统癌症治疗方法的疗效。研究表明：尼古丁在促进肿瘤发生、进展和抗癌症治疗等过程中扮演着重要的角色。
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