Objective:To evaluate the relationship between augmentation index (AI) and early renal damage in overweight or obesity patients with hypertension.Methods:189 patients in our hospital from January to June 2015 were selected and divided into normal body mass index (Ibm) group(Ibm＜24 kg/mm2,n=80),overweight group (Ibm 24-28 kg/mm2,n=70) and obesity group (Ibm＞28 kg/mm2,n=39).The AI,systolic blood pressure (SBP),diastolic blood pressure (DBP),creatinine clearance rate (Ccr),fasting blood glucose (FBG),postprandial blood glucose (PBG),low density lipoprotein-cholesterol (LDL-C),high density lipoprotein-cholesterol (HDL-C) and 24 h microalbuminuria (MAU) were detected.Results:There was significant difference in Ibm among groups (P＜0.05),but no statistical difference was found in the age,SBP,DBP,Ccr,FBG,PBG,and LDL-C among the three groups (P＜0.05).The HDL-C level in normal Ibm group was significantly higher than the overweight group and obesity group (P＜0.05),and was slightly higher in the overweight group than the obesity group (P＞0.05).The AI and 24 h MAU level were higher in overweight and obesity groups than in normal Ibm group,and were higher in overweight group than in the obesity group (P＜0.05).Multiple linear regression analysis showed that AI was still a risk factor for high-level of 24 h MAU after regulation of age,sex,blood glucose,blood pressure and blood lipid factors.Conclusion:AI may be a predictor for early stage renal damage in patients with hypertension combined with excessive weight or obesity.%目的:探讨反射波增强指数(AI)与超重或肥胖的高血压患者早期肾损害的关系.方法:选取2015年1-6月在广西医科大学第一附属医院高血压病区治疗的189例原发性高血压患者,根据体重指数(Ibm)分为Ibm正常组(Ibm＜24 kg/mm2,n=80)、超重组(Ibm 24～28 kg/mm2,n=70)及肥胖组(Ibm＞28 kg/mm2,n=39).测定各组Ibm、平均收缩压(SBP)、舒张压(DBP)、内生肌酐清除率(Ccr)、空腹血糖(FBG)、餐后2h血糖(PBG)、血清低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、AI及24 h尿微量白蛋白.结果:3组Ibm比较差异有统计学意义(P＜0.05),而年龄、SBP、DBP、Ccr、FBG、PBG、LDL-C比较差异均无统计学意义(均P＞0.05).Ibm正常组的HDL-C明显高于超重组和肥胖组(P＜0.05),且超重组的HDL-C稍高于肥胖组(P＞0.05).超重组和肥胖组的AI、24 h尿微量白蛋白水平均高于Ibm正常组,且肥胖组高于超重组,差异均有统计学意义(均P＜0.05).多元线性回归分析结果显示,调整年龄、性别、血糖、血压、血脂因素后,AI仍是24 h尿微量白蛋白增高的独立危险因素(P＜0.05).结论:AI可作为超重或肥胖的高血压患者早期肾损害的指标.
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