目的:探讨肾血管性高血压大鼠左心室肥厚和ICAM-1之间的关系.方法:将20只雄性SD大鼠,体重200～250 g,随机分两组:手术组及假手术组,每组10只.手术组行二肾一夹手术,假手术组行假手术.术前及术后每4周测鼠尾动脉血压1次.术后12周处死动物.结果:(1)术后4周,手术组收缩血压升高超过20 kPa,与假手术组相比,手术组血压明显升高(P＜0.05).(2)手术组的左室肥厚相关指标明显高于假手术组(P＜0.05).(3)手术组的ICAM-1的蛋白表达明显高于假手术组(P＜0.05).结论:肾血管性高血压左心室肥厚可能与炎性因子ICAM-1的蛋白表达增加及其所介导的炎症反应有关.%Objective: To explore the relationship between left ventricular hypertrophy ( LVH) and ICAM-1 in rats with renovascular hypertension. Methods:Twenty male SD rats weighing 200~250 g were randomly divided into operation and sham-operated groups ( n = 10 for each). Operation group -was made -with two kidneys, one clip (2K1C) operation while sham-operated group -was made -with sham operation. Blood pressure -was measured before operation and every 4 weeks after operation. Animals were killed 12 weeks after operation. Results: (1) Blood pressure in operation group increased more than 20 kPa 4 weeks after operation. As compared with sham-operated group, blood pressure in operation group -was higher ( P <0. 05). (2) LVH index in operation group was higher than that in sham-operated group ( P <0. 05). (3) Protein expression of ICAM-1 in operation group was higher than that in sham-operated group ( P <0. 05). Conclusion: LVH in renovascular hypertension might be associated with the increased expression of ICAM-1 protein and the imflammatory reaction mediated by ICAM-1.
展开▼
