Objective: A systematic review -was conducted to evaluate the accuracy of -whole-body PET and PET-CT in determining bone metastsis in patients -with head and neck cancer. Methods: After a systematic review of English language articles, sensitivity, specificity, and other measures of -whole-body PET and PET-CT were pooled using bivariate models. Summary receiver operating characteristic curves were also used to summarize overall test performance. Results: Eight PET studies (1 541 patients) and eight PET-CT studies (1 129 patients) were included. The summary sensitivity estimates for whole-body PET and PET-CT in the selected studies were 0.84 (95% CI:0. 51 to 0.96) and 0. 95 (95 % CI: 0.82 to 0.99). The specificity was 0. 99(95%CI:0. 97 to 1.00) and 0. 99(95%CI:0. 98 to 0. 99). The area under curves of PET and PET-CT was 0. 99(95%CI:0. 98 to 1. 00) and 1. 00(95%CI:0. 99 to 1. 00). Conclusion: Whole-body PET-CT and PET have high diagnostic value in determining bone metastsis in patients -with head and neck cancer. Both have similar diagnostic accuracy. But PET-CT tends to have higher sensitivity than PET.%目的:系统评价全身PET和PET-CT 在判断头颈部癌骨转移价值的准确性.方法:对英文文献进行系统评价,利用bivariate模型汇总计算出全身PET和PET-CT的敏感性、特异性及其他指标,并绘制汇总受试者工作曲线,探讨其总的诊断效能.结果:8个PET研究(1 541例患者)和8个PET-CT研究(1 129例患者)纳入分析.纳入研究中全身PET和PET-CT的总体敏感性分别为0.84(95%CI:0.51～0.96)和0.95(95%CI:0.82～0.99);特异性为0.99(95%CI:0.97～1.00)和0.99(95%CI:0.98～0.99);PET和PET-CT的曲线下面积分别为0.99(95%CI:0.98～1.00)和1.00(95%CI:0.99～1.00).结论:全身PET-CT和PET在检测头颈部癌骨转移均具有较高价值,但PET-CT有比PET提高敏感性的趋势.
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