Effects of Yiqi Gu Ben Decoction combined with DC chemotherapy on serum tumor markers, inflammatory factors and immune function in patients with locally advanced non-small cell lung cancer

Min Duan; Chun-Fang Jia; Xin Duan

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Effects of Yiqi Gu Ben Decoction combined with DC chemotherapy on serum tumor markers, inflammatory factors and immune function in patients with locally advanced non-small cell lung cancer

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Objective: To investigate the effects of Yiqi Gu decoction combined with DC chemotherapy on serum tumor markers, inflammatory factors and immune function in patients with locally advanced non-small cell lung cancer. Methods: A total of 95 patients with locally advanced non-small cell lung cancer were selected as the research objects, according to the random data table they were divided into control group (n=48) and observation group (n=47), patients in the control group were given DC chemotherapy, On the basis of this treatment, the patients in the observation group were given Yiqi Gu decoction treatment, Comparison of the levels of serum tumor markers [antigen (CEA) and carbohydrate antigen 19-9 (CA19-9)], inflammatory factor [C reactive protein (CRP) and tumor necrosis factor-α (TNF-α)] and immune function [CD3+, CD4+, CD8+, CD4+/CD8+]. Results: Before treatment, there were no significant difference in the levels of CEA, CA19-9, CRP, TNF-α, CD3+, CD4+, CD8+, CD4+/CD8+ between the two groups; After treatment, the CEA, CA19-9, CRP, TNF-α, CD8+ levels of two groups were significantly lower than those in the same group before treatment, and the decreased range in observation group was significantly higher than the control group, moreover the levels after treatment were obviously lower than control group; After treatment, the levels of CD3+, CD4+, CD4+/CD8+ in the observation group were (64.72±5.25)％ , (39.51±5.14)％ and (1.35±0.27), which were significantly higher than the same group before treatment, and significantly higher than the control group [(58.57±5.09)％, (31.34±5.06)％, (1.14±0.33)], differences were statistically significant. Conclusion: DC chemotherapy combined with Yiqi Guben Decoction in the treatment of locally advanced non-small cell lung cancer, can effectively reduce the serum tumor marker levels, decrease inflammatory stress, improve immune function, has an important clinical value.

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《海南医科大学学报（英文版）》 |2018年第1期|85-88|共4页
作者
Min Duan; Chun-Fang Jia; Xin Duan;
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Department of Clinical Laboratory,Zhangbei Disease Control and Prevention Center,Hebei,Zhangjiakou 076450,China;

Department of Internal Medicine,Zhangbei Hospital of Traditional Chinese Medicine,Hebei,Zhangjiakou 076450,China;

Department of Internal Medicine,Zhangbei Hospital of Traditional Chinese Medicine,Hebei,Zhangjiakou 076450,China;

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Effects of Yiqi Gu Ben Decoction combined with DC chemotherapy on serum tumor markers, inflammatory factors and immune function in patients with locally advanced non-small cell lung cancer

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