Effect of cinepazide combined with mecobalamine on nerve conduction velocity, vibration perception threshold and serum indexes in patients with diabetic peripheral neuropathy

Jue-Zhang Ou; Xiang Jia; Shu-Qun Chen

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Effect of cinepazide combined with mecobalamine on nerve conduction velocity, vibration perception threshold and serum indexes in patients with diabetic peripheral neuropathy

机译：赛帕齐特联合甲钴胺对糖尿病周围神经病患者神经传导速度，振动知觉阈和血清指标的影响

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Objective:To analyze the effect of cinepazide combined with mecobalamine on nerve conduction velocity, vibration perception threshold and serum indexes in patients with diabetic peripheral neuropathy. Methods:90 patients with diabetic peripheral neuropathy treated in our hospital between March 2013 and March 2016 were selected and divided into observation group and control group (n=45) according to random number table, control group received mecobalamine treatment alone and observation group accepted the cinepazide combined with mecobalamine therapy. Differences in nerve conduction velocity, vibration perception threshold as well as serum oxidative stress indexes and nerve injury marker molecules were compared between two groups of patients 2 weeks after treatment. Results:2 weeks after treatment, median nerve, ulnar nerve and peroneal nerve sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) levels of observation group were higher than those of control group (P<0.05) while both lower extremities vibration perception threshold (VPT) levels were lower than those of control group (P<0.05). Serum homocysteine (HCY), advanced glycosylation end products (AGEs), malondialdehyde (MDA), neuron-specific enolase (NSE), high mobility group B1 (HMGB1) and S100βcontent of observation group were lower than those of control group (P<0.05) while reduced glutathione (GSH), superoxide dismutase (SOD), myelin basic protein (MBP) and brain-derived neurotrophic factor (BDNF) content were higher than those of control group (P<0.05). Conclusions:Cinepazide combined with mecobalamine can reduce the nerve injury degree, improve nerve conduction and vibration perception and alleviate the oxidative stress degree in patients with diabetic peripheral neuropathy.

机译：目的：分析西那哌齐联合甲钴胺对糖尿病周围神经病患者神经传导速度，振动知觉阈值和血清指标的影响。方法：选择2013年3月至2016年3月在我院治疗的90例糖尿病周围神经病患者，根据随机数字表分为观察组和对照组（n = 45），对照组单独接受甲钴胺治疗，观察组接受治疗。塞哌齐联合甲钴胺治疗。比较两组患者在治疗后2周的神经传导速度，振动知觉阈值，血清氧化应激指数和神经损伤标记分子的差异。结果：治疗2周，观察组中位神经，尺神经和腓神经感觉神经传导速度（SNCV）和运动神经传导速度（MNCV）水平均高于对照组（P <0.05），而下肢振动知觉阈值（VPT）水平低于对照组（P <0.05）。观察组血清高半胱氨酸（HCY），晚期糖基化终产物（AGEs），丙二醛（MDA），神经元特异性烯醇酶（NSE），高迁移率B1组（HMGB1）和S100β含量均低于对照组（P <0.05 ）而降低的谷胱甘肽（GSH），超氧化物歧化酶（SOD），髓鞘碱性蛋白（MBP）和脑源性神经营养因子（BDNF）含量高于对照组（P <0.05）。结论：Cinepazide联合甲钴胺可减轻糖尿病周围神经病患者的神经损伤程度，改善神经传导和振动知觉，减轻氧化应激程度。

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《海南医科大学学报（英文版）》 |2017年第3期|68-71|共4页
作者
Jue-Zhang Ou; Xiang Jia; Shu-Qun Chen;
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Endocrinology Department, Wuyi Hospital of Traditional Chinese Medicine of Jiangmen City Guangdong Province, Jiangmen 529000, China;

Endocrinology Department, Guangzhou Hospital of Integrated Chinese and Western Medicine of Guangdong Province, Guangzhou 510801, China;

Physical Examination Center, Wuyi Hospital of Traditional Chinese Medicine of Jiangmen City Guangdong Province, Jiangmen 529000, China;

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Effect of cinepazide combined with mecobalamine on nerve conduction velocity, vibration perception threshold and serum indexes in patients with diabetic peripheral neuropathy

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