Value and significance of tumor markers as CEA,CA125,SCC-Ag,CA199 and CYFRA21-1 in the diagnosis of cervical cancer

Xiao-Juan Wang; Qin San; Yue-Ming Wang; Ying-Ying Cui; Rui Sun; Guang-Zhi Chen

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Value and significance of tumor markers as CEA,CA125,SCC-Ag,CA199 and CYFRA21-1 in the diagnosis of cervical cancer

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Objective: To investigate the value and significance of serum CEA, CA125, SCC-Ag, CA199 and CYFRA21-1 in the diagnosis of cervical cancer by comparing the detection of five serum markers. Methods: A total of 108 cases were divided into three groups, including 60 cervical cancerpatients and 20 cervical intraepithelial neoplasiain patients treated in our hospital from September 2015 to September 2016 and 28 healthy women. Radioimmunoassay was used to detect and compare the serum levels of CA125, CA199, CYFRA21-1 and ELISA method was used to detect and compare the serum levels of SCC-Ag, CEA. Results: (1) There was no statistically significant difference in the serum CEA, CA125, SCC-Ag, CA199, CYFRA21-1 levels between CIN group and control group. The serums CEA, CA125, SCC-Ag, CA199, CYFRA21-1 levels of cervical cancer patients were significantly higher than the other two groups. The differences were statistically significant. (2)There were statistically significant differences in the serum CEA, CA125, SCC-Ag, CA199, CYFRA21-1 levels between different cervical pathological type groups.The serum CA125, CA199, CEA levels of cervical glandular cancer patients were significantly higher than the other two groups. The differences were statistically significant. The serum SCC-Ag, CYFRA21-1 levels of cervical squamous cancer patients were significantly higher than the other two groups. The differences were statistically significant. Conclusion: The serums CEA, CA125, SCC-Ag, CA199, CYFRA21-1 levels of cervical cancer patients were significantly higher than cervical intraepithelial neoplasiain patients and healthy women. The serum CA125, CA199, CEA levels of cervical glandular cancer patients were significantly higher and the serum SCC-Ag, CYFRA21-1 levels of cervical squamous cancer patients were significantly higher. The five tumor markers can be used in diagnosis of cervical cancer and they are also worthy in distinguishing cervical pathological types.

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《海南医科大学学报（英文版）》 |2017年第18期|132-135|共4页
作者
Xiao-Juan Wang; Qin San; Yue-Ming Wang; Ying-Ying Cui; Rui Sun; Guang-Zhi Chen;
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Clinical Laboratory, Shiyan Maternal and Child Health-Care Hospital, Shiyan Hubei 442000 China;

Clinical Laboratory, Shiyan Maternal and Child Health-Care Hospital, Shiyan Hubei 442000 China;

Clinical Laboratory, Shiyan Maternal and Child Health-Care Hospital, Shiyan Hubei 442000 China;

Clinical Laboratory, Shiyan Maternal and Child Health-Care Hospital, Shiyan Hubei 442000 China;

Clinical Laboratory, Shiyan Maternal and Child Health-Care Hospital, Shiyan Hubei 442000 China;

Oncology Department, Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430034 China;

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Value and significance of tumor markers as CEA,CA125,SCC-Ag,CA199 and CYFRA21-1 in the diagnosis of cervical cancer

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