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《海南医科大学学报（英文版）》
>Effects of tripterygium wilfordii combined with Salvia Miltiorrhiza therapy on renal function, coagulation function and immune response in children with purpura nephritis
Effects of tripterygium wilfordii combined with Salvia Miltiorrhiza therapy on renal function, coagulation function and immune response in children with purpura nephritis
Objective: To investigate the effects of tripterygium wilfordii combined with Salvia Miltiorrhiza therapy on renal function, coagulation function and immune response in children with purpura nephritis. Methods: A total of 70 children with purpura nephritis who were treated in the hospital between October 2013 and March 2017 were divided into control group (n=35) and Salvia Miltiorrhiza group (n=35) by random number table. Control group received routine + tripterygium wilfordii therapy, Salvia Miltiorrhiza group received routine+ tripterygium wilfordii + Salvia Miltiorrhiza therapy, and the therapies lasted for 3 courses. The differences in renal function, coagulation function and immune response were compared between the two groups before and after treatment. Results: Before treatment, there was no statistically significant difference in renal function, coagulation function and immune response function between the two groups. After 3 courses of treatment, renal function indexes CysC,β2MG and 24 h UmAlb levels in Salvia Miltiorrhiza group were lower than those in control group; coagulation function indexes FIB and D-D levels in peripheral blood were lower than those of control group; immune response indexes Th1 cytokines IL-2 and IFN-γ contents in peripheral blood were higher than those of control group whereas Th2 cytokines IL-5 and IL-10 contents were lower than those of control group. Conclusion: Tripterygium wilfordii combined with Salvia Miltiorrhiza therapy can effectively optimize the renal function, reduce the hypercoagulation state and reduce the Th1/Th2 immune imbalance in children with purpura nephritis.
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