Effects of montelukast sodium combined with budesonide on lung function, inflammatory factors and immunoglobulin levels in children with asthma

Ying-Li Liu; Mei-Jia Xu; Wei Lyu; Ji-Ying Zhang; Ming-Zhu Gui

首页> 中文期刊> 《海南医科大学学报（英文版）》 >Effects of montelukast sodium combined with budesonide on lung function, inflammatory factors and immunoglobulin levels in children with asthma

Effects of montelukast sodium combined with budesonide on lung function, inflammatory factors and immunoglobulin levels in children with asthma

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Objective: To investigate the effects of montelukast sodium combined with budesonide on pulmonary function, inflammatory factors and immunoglobulin in children with asthma. Methods: A total of 100 children with asthma treated in our hospital from May 2013 to November 2016 were randomly divided into control group and observation group. In the control group, budesonide inhalation therapy was given. On the basis of the control group, montelukast sodium treatment was given, pulmonary function, inflammatory factors and immunoglobulin levels in the two groups before and after treatment were measured. Results:Compared with before treatment, the levels of FEV1％, FEF50％, FEF25％ and PEF％ in the two groups were significantly increased, those in the observation group were higher than in control group; compared with before treatment, IL-10 levels were significantly increased, TNF-α and IL-8 levels were significantly decreased in the two groups after treatment, moreover those in the observation group IL-10 levels were significantly higher than the control group, TNF-α and IL-8 were significantly lower than those in the control group, the difference was statistically significant; Compared with before treatment, IgA and IgM levels were significantly increased in both groups after treatment, IgE levels were significantly decreased, and IgA and IgM levels in the observation group were significantly higher than in the control group, IgE levels were significantly lower than the control group, the difference was statistically. Conclusion: Montelukast sodium combined with budesonide can effectively reduce the inflammation level of children with asthma, improve lung function, enhance immunity, the effect is significant, it is worth further clinical application.

著录项

来源
《海南医科大学学报（英文版）》 |2017年第24期|77-80|共4页
作者
Ying-Li Liu; Mei-Jia Xu; Wei Lyu; Ji-Ying Zhang; Ming-Zhu Gui;
展开▼
作者单位

Department of Pediatrics, the Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 201999, China;

Department of Pediatrics, the Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 201999, China;

Department of Pediatrics, the Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 201999, China;

Department of Pediatrics, Amcare Women's & Children's Hospital, Hangzhou 310000, China;

Department of Pediatrics, Luodian Hospital of Shanghai Baoshan District, Shanghai 201908, China;

展开▼
原文格式 PDF
正文语种 eng
中图分类
关键词

Effects of montelukast sodium combined with budesonide on lung function, inflammatory factors and immunoglobulin levels in children with asthma

摘要

著录项

相关主题

期刊订阅