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《海南医科大学学报(英文版)》
>Effect of high flux hemodialysis on plasma toxin molecule contents and body’s microinflammatory state in patients with uremia
Effect of high flux hemodialysis on plasma toxin molecule contents and body’s microinflammatory state in patients with uremia
Objective:To analyze the effect of high flux hemodialysis on plasma toxin molecule contents and body’s microinflammatory state in patients with uremia. Methods:A total of 96 cases of patients with uremia receiving inpatient dialysis in our hospital from June 2011 to March 2015 were selected as research subjects and randomly divided into observation group and control group, each group with 48 cases. Control group received low flux hemodialysis (LF-HD), observation group received high flux hemodialysis (HF-HD), and then levels of plasma renal function-related toxins, oxidative stress-related toxins, leptin, intact parathyroid hormone and asymmetric dimethylarginine as well as levels of microinflammatory state-related factors of two groups were compared. Results:Plasma BUN, Scr, UA andβ2-MG levels of observation group after dialysis were significantly lower than those of control group;plasma MDA and Cor levels of observation group after dialysis were lower than those of control group, and levels of GSH and SOD were higher than those of control group;plasma Leptin, iPTH and ADMA levels of observation group after 1 time and 5 times of dialysis were significantly lower than those of control group;plasma hs-CRP, IL-6, TNF-αand ASAA levels of observation group after dialysis were significantly lower than those of control group. Conclusion:High flux hemodialysis for patients with uremia can effectively eliminate related toxins in the body and reduce systemic microinflammatory state, and it has active clinical significance.
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