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《海南医科大学学报(英文版)》
>Effects of combined therapy of traditional Chinese medicine and western medicine on platelets, coagulative functions and inflammatory cytokines with ulcerative colitis
Effects of combined therapy of traditional Chinese medicine and western medicine on platelets, coagulative functions and inflammatory cytokines with ulcerative colitis
Objective:To explore the effects of combined therapy of traditional Chinese medicine and western medicine on platelets, coagulative functions and inflammatory cytokines in patients with ulcerative colitis (UC). Methods:A total of 267 patients with UC were collected. 137 patients were treated with combined therapy of traditional Chinese medicine and western medicine as experimental group and 130 patients were treated with only western medicine as controls. Platelet count, coagulation function indexes and inflammatory cytokines were measured before and 15 d after the treatment. Results:No significantly differences were found in all indexes before treatment between two groups. After different treatments, platelet count (PLT), platelet distribution width (PDW) were significantly decreased in both groups, but mean platelet volumn (MPV) were significantly increased than before treatment. PLT and PDW were significantly lower and MPV were significantly higher in experimental group than control group. Fibrinogen (Fib) and D-dimer (DD) decreased significantly after treatment. Fib and DD in experimental group were significantly lower than controls. No significantly differences were found in activated partial thromboplastin time (APTT) and prothrobin time (PT). Tumor necrosisi factor-α(TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) decreased significantly in both group after treatment. TNF-α, IL-6 and IL-8 were significantly lower in experimental group than controls. Conclusion:Combined therapy of traditional Chinese medicine and western medicine can more effectively improve the cogulation, fibrinolysis and inflammation in patients with UC than only western medicine therapy.
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