Objective:To study the effect of pidotimod combined with ribavirin treatment on serum indexes of children with hand-foot-mouth disease.Methods:A total of 78 children with hand-foot-mouth disease who received pidotimod combined with ribavirin treatment in our hospital from May 2013 to December 2015 were selected as the experimental group of the research, 84 children with hand-foot-mouth disease who received ribavirin monotherapy in our hospital from January 2012 to April 2013 were selected as the control group of the research. Serum inflammatory response indexes and biochemical indexes and immune function indexes of two groups were compared.Results: During the treatment, the maculopapule and herpes progression of experimental group were significantly better than those of control group; 7 day after treatment, CD3+CD4+CD8-T cell, CD3+CD4-CD8+T cell, CD19+B cell, CD14highCD16+monocyte and CD14lowCD16+ monocyte content in peripheral blood of experimental group were significantly higher than those of control group, serum CRP, IL-6 and IL-10 levels were significantly lower than those of control group, and blood insulin, blood glucose, lactic acid, D-dimer and procalcitonin levels were significantly lower than those of control group. Conclusions:Pidotimod combined with ribavirin treatment can improve maculopapule and herpes, enhance immune function and reduce inflammatory reaction, and it is an ideal treatment for the treatment of children with hand-foot-mouth disease.
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