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《海南医科大学学报(英文版)》
>Effect of different hypoglycemic scheme ion serum inflammatory factors and blood hypercoagulability on patients with type 2 diabetes mellitus
Effect of different hypoglycemic scheme ion serum inflammatory factors and blood hypercoagulability on patients with type 2 diabetes mellitus
Objective:To observe the effect of different hypoglycemic scheme on serum inflammatory factors and blood hypercoagulability in patients with type 2 diabetes mellitus (T2DM). Methods:A total of 186 cases patient with T2DM were randomly divided into 3 groups according to the different hypoglycemic scheme, such as: insulin group (69 cases), oral drug group (58 cases) and combination group (60 cases). Insulin group was given insulin aspart; oral drug group was given metformin and pioglitazone; combination group was given insulin aspart and metformin. For 6 mouths, to observe the different of serum inflammatory factorsα(TNF-α, hs-CRP, IL-6, MCP-1) and blood hypercoagulabilit indexes (PT, APTT, TT, FIB, PLT, TXB2) between the three groups.Results: After treatment, TNF-α, hs-CRP, IL-6, MCP-1 of the three groups were decreased with before (P0.05). After treatment, except PLT was no change, PT, APTT, TT of the three groups were increased and FIB, TXB2 were decreased with before (P0.05).Conclusions:All of the 3 hypoglycemic schemes are beneficial to reduce the inflammatory reaction and relieve the blood hypercoagulability, but the effect of insulin combined with oral drug is the best.
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