Effects of laparoscopic minimally invasive surgery on coagulation, antioxidant function, angiogenesis, IGF-1 and IFN-γ levels in rectal cancer patients

Chun-Guang Zhang; Qing-Ya Tan; Yuan-Li Kuang; Zhi-Ming Tan

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Effects of laparoscopic minimally invasive surgery on coagulation, antioxidant function, angiogenesis, IGF-1 and IFN-γ levels in rectal cancer patients

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Objective: To investigate the effects of laparoscopic minimally invasive surgery on coagulation, antioxidant function, angiogenesis, IGF-1 and IFN-γ levels in rectal cancer patients. Methods: A total of 90 patients with rectal cancer admitted to general surgery in our hospital from March 2016 to December 2017 were randomly divided into control group (n=45) and observation group (n=45), the control group underwent conventional open surgery and the observation group underwent laparoscopic radical resection. The blood coagulation function, antioxidant capacity, angiogenesis, IGF-1 and IFN-γ levels were compared between the two groups. Results: Before treatment, there was no significant difference in coagulation function, antioxidant capacity, angiogenesis, IGF-1 and IFN-γ levels between the two groups. After treatment, there was no significant difference in PT and APTT between the two groups, while FIB and DD were significantly increased compared with before treatment, and the FIB and DD of the observation group increased significantly compared with the control group; the SOD and GSH of the two groups were significantly lower than those before treatment, while the MDA was significantly increased compared with that before treatment, the decrease of SOD, GSH and the increase of MDA in the observation group was significantly greater than that of the control group; the levels of VEGF and MMP-9 in the two groups were significantly lower than those before treatment, and the VEGF and MMP-9 in the observation group were significantly lower than those in the control group; the levels of IGF-1 in the two groups were significantly lower than those before treatment, and the IGF-1 in the observation group was significantly lower than that in the control group; the IFN-γ levels in the two groups were significantly higher than those before treatment, and the IFN-γ was significantly increased in the observation group compared with the control group. Conclusions: Laparoscopic surgery for patients with rectal cancer can easily cause hypercoagulable state of the patient's blood, but it can effectively avoid tumor metastasis and less stress damage, and further promote the rehabilitation of the patients, which is worthy of clinical promotion.

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《海南医科大学学报（英文版）》 |2018年第21期|61-64|共4页
作者
Chun-Guang Zhang; Qing-Ya Tan; Yuan-Li Kuang; Zhi-Ming Tan;
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Department of General Surgery, Chongqing Kaizhou District People's Hospital, Chongqing 405400, China;

Respiratory Medicine, Chongqing Kaizhou District People's Hospital, Chongqing 405400, China;

Department of General Surgery, Chongqing Kaizhou District People's Hospital, Chongqing 405400, China;

Department of General Surgery, Chongqing Kaizhou District People's Hospital, Chongqing 405400, China;

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Effects of laparoscopic minimally invasive surgery on coagulation, antioxidant function, angiogenesis, IGF-1 and IFN-γ levels in rectal cancer patients

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