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首页> 中文期刊> 《海南医科大学学报（英文版）》 >Correlation of the BRAFV600E and RAS mutations with clinicopathological characteristics of papillary thyroid cancer using TCGA database analysis

Correlation of the BRAFV600E and RAS mutations with clinicopathological characteristics of papillary thyroid cancer using TCGA database analysis

         
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摘要

Objective:To investigate the occurrence of BRAFV600E and RAS mutations in thyroid papillary carcinoma (PTC) and to study their correlation with clinicopathological features of PTC. Methods Relevant information of PTC was downloaded and organized from The Cancer Genome Atlas (TCGA) via cBioPortal, then the gene mutation and clinical information of 402 PTC samples were analyzed. The correlation of BRAFV600E and RAS mutations with clinicopathological features and prognosis of PTC were subjected to univariate analysis. Secondly, we use Binary Logistic multivariate analysis to analyze the factors screened above. Results BRAFV600E mutation rate is 48.5％ (195/402) and RAS mutation rate is 10.2％ (41/402) in 402 cases of PTC. Univariate analysis showed that BRAFV600E mutation has nothing to do with age and sex of the patient. There is a significant correlation among BRAFV600E mutation and lymph node metastasis, extrathyroidal invasion, staging, recurrence, progression and pathological subtypes in PTC. There is no significant correlation among RAS and age, sex, staging, recurrence, progression. There is a significant correlation among RAS and lymph node metastasis, extrathyroidal invasion and pathological subtypes in PTC. Multivariate logistic regression analysis indicated that there is a significant correlation among BRAFV600E mutation and extrathyroidal invasion, pathological subtypes in PTC. There is a significant correlation among RAS and lymph node metastasis, extrathyroidal invasion and pathological subtypes in PTC.ConclusionThe mutation rate of BRAFV600E was significantly higher than that of RAS in PTC. Mutations in BRAFV600E and RAS can be used as predictors of prognosis in PTC.

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  • 来源
    《海南医科大学学报（英文版）》 |2019年第1期|1-4|共4页
  • 作者

    Yue Zhao; Bing-Jie Wu; Duo-Duo Wang; Chun-Rong Liu; Jia-Jia Sun; Guang-Lei Zhou; Jing-Hao Huang; Feng-Yun Wu;

  • 作者单位

    Logistics University of Chinese People's Armed Police Force, Tianjin, 300309, China;

    Department of Thyroid and Breast Surgery, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, 300162, China;

    Graduate School, Tianjin Medical University, Tianjin, 300070, China;

    Graduate School, Anhui Medical University, Hefei, Anhui Province, 200233, China;

    Logistics University of Chinese People's Armed Police Force, Tianjin, 300309, China;

    Department of Thyroid and Breast Surgery, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, 300162, China;

    Department of Thyroid and Breast Surgery, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, 300162, China;

    Department of Thyroid and Breast Surgery, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, 300162, China;

    Department of Thyroid and Breast Surgery, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, 300162, China;

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