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Expression of FZD10 in gastric cancer and its effect on gastric cancer cells

机译：FZD10在胃癌中的表达及其对胃癌细胞的影响

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摘要

Objective:To investigate the expressions of FZD10 and its effect on gastric cancer cells. Methods: The expression of FZD10 in gastric cancer tissues and adjacent cancer tissues was detected by immunohistochemistry; The gastric cancer cell lines AGS and MGC-803 were transfected with siRNA, and then use Western-blot to analysis the transfection efficiency;The proliferation and invasion ability of gastric cancer cell was analyzed by CCK-8 and wound heal.Results: The expression of FZD10 in gastric cancer was significantly higher than that in adjacent tissues (P<0.05). Compared with the blank control group, the proliferation and cell invasion ability of siRNA transfected with AGS and MGC-803 decreased significantly(P<0.05), while the blank control group and empty control group No significant difference between the negative control groups (P>0.05).Conclusion: The expressions of FZD10 significantly up-regulated in gastric cancer, and silencing its expression will affect the proliferation and invasive ability of gastric cancer cells.
机译：目的：探讨FZD10的表达及其对胃癌细胞的影响。方法：采用免疫组织化学方法检测FZD10在胃癌及癌旁组织中的表达。用siRNA转染胃癌细胞系AGS和MGC-803，然后用Western-blot分析其转染效率; CCK-8分析胃癌细胞的增殖和侵袭能力，并观察伤口愈合情况。胃癌中FZD10的表达明显高于癌旁组织（P <0.05）。与空白对照组相比，转染了AGS和MGC-803的siRNA的增殖和细胞侵袭能力显着下降（P <0.05），而空白对照组和空对照组与阴性对照组相比无显着性差异（P> 0.05）。 0.05）。结论：FZD10在胃癌中的表达明显上调，其沉默会影响胃癌细胞的增殖和侵袭能力。

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  • 来源
    《海南医科大学学报（英文版）》 |2019年第11期|53-56|共4页
  • 作者

    Chang-Wang Chen; Zhang Wang; Ling Zhou; Jian-Hua Sun; Bi-Tao Zhang;

  • 作者单位

    Department of Gastrointestinal Surgery, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei Province, 445000, China;

    Department of Gastrointestinal Surgery, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei Province, 445000, China;

    Department of Gastrointestinal Surgery, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei Province, 445000, China;

    Department of Gastrointestinal Surgery, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei Province, 445000, China;

    Department of Gastrointestinal Surgery, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei Province, 445000, China;

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