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首页> 中文期刊> 《海南医科大学学报（英文版）》 >The related effects of astragalus polysaccharides on the improvement of bone marrow suppression and hematopoietic stem cells during chemotherapy in elderly patients with lung cancer

The related effects of astragalus polysaccharides on the improvement of bone marrow suppression and hematopoietic stem cells during chemotherapy in elderly patients with lung cancer

         
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摘要

Objective:To investigate the effects of astragalus polysaccharides(APS)on bone marrow suppression and hematopoietic stem cells during chemotherapy in elderly patients with lung cancer.Methods:120 elderly patients with lung cancer treated in the first hospital of Xingtai city from January 2019 to early December 2019 were divided into the treatment group and the control group by the random number table method,all of whom received pemetrexed+carboplatin chemotherapy,and the treatment group was treated with APS at the same time.The efficacy was evaluated after 2 cycles of chemotherapy,bone marrow suppression was observed,and levels of TCM symptoms score,peripheral blood T lymphocyte subgroup index,L-selectin(CD62L)and macrophage differentiation antigen-1(Mac-1)were measured before and after 2 cycles of chemotherapy.Results:The response rate(RR)was 56.67%in the treatment group and 45.00%in the control group,with no statistically significant difference(P>0.05);The disease control rate(DCR)in the treatment group was 81.67%,which was significantly higher than 65.00%in the control group(P0.05).Conclusion:Astragalus polysaccharide can improve the chemotherapy effect and improve the bone marrow suppression in elderly patients with lung cancer,which may be related to its obvious enhancement of immune function and decrease of CD62L and Mac-1 levels.

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  • 来源
    《海南医科大学学报（英文版）》 |2020年第19期|30-35|共6页
  • 作者

    Ya-Ning Gong; Shuai Wang; Jing Zhang; Yi-Bing Liu; Xin-Li Tian;

  • 作者单位

    First Affiliated Hospital of Xingtai Medical College (Xingtai First Hospital) 054000;

    First Affiliated Hospital of Xingtai Medical College (Xingtai First Hospital) 054000;

    First Affiliated Hospital of Xingtai Medical College (Xingtai First Hospital) 054000;

    First Affiliated Hospital of Xingtai Medical College (Xingtai First Hospital) 054000;

    First Affiliated Hospital of Xingtai Medical College (Xingtai First Hospital) 054000;

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  • 正文语种 eng
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