The Mechanism of the combination of radix paeoniae rubra-cortex moutan in treating cerebral hemorrhage based on network pharmacology

Jia-Qi Chen; Ge-Sheng Wang; Yu-Jia Zhou; Jia-Lin Liu; Guang-Rong Song; Zhen-Zhen Pei; Can Zheng

首页> 中文期刊> 《海南医科大学学报（英文版）》 >The Mechanism of the combination of radix paeoniae rubra-cortex moutan in treating cerebral hemorrhage based on network pharmacology

The Mechanism of the combination of radix paeoniae rubra-cortex moutan in treating cerebral hemorrhage based on network pharmacology

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Objective:To clarify the material basis of Chinese medicine pair“Radix Paeoniae Rubra-Cortex Moutan”(Chishao-Mudanpi)and explore their mechanism in the treatment of ICH with network pharmacology.Methods:The active ingredients contained in Radix Paeoniae Rubra and Cortex Moutan were searched and selected based on the oral bioavailability prediction and drug-likeness prediction from the TCMSP database.Then the targets of cerebral hemorrhage were collected from GeneCards,OMIM,and DrugBank databases.After obtained the intersections of drugs and disease,the active component target disease interactive network diagram was drawn by Cytoscape software.The obtained key targets were uploaded to the STRING database for analysis and construct a PPI network map.GO function enrichment analysis and KEGG analysis were performed on the key target proteins.Results:Collected the active ingredients of Radix Paeoniae 119,Radix Paeoniae 55,including paeoniflorin,baicalin,β-sitosterol,etc.Related drug target protein 1190,ICH disease-related genes 823,"Radix Paeoniae-Radix Paeoniae"and 72 common targets of ICH,mainly acting on Akt1,IL6,VEGFA,CASP3,EGF,involving 133 related signaling pathways such as AGE-RAGE,TNF,IL-17,HIF1,PI3K-Akt.Conclusion:The combination of"Radix Paeoniae Rubra-Cortex Moutan"in the treatment of ICH has the characteristics of multiple pathways and multiple targets,which provides a reference and basis for further molecular biology verification in the future.

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《海南医科大学学报（英文版）》 |2021年第2期|51-57|共7页
作者
Jia-Qi Chen; Ge-Sheng Wang; Yu-Jia Zhou; Jia-Lin Liu; Guang-Rong Song; Zhen-Zhen Pei; Can Zheng;
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Beijing University of TCM Beijing China 100029;

Dongfang Hospital of Beijing University of TCM Beijing China 100078;

Dongfang Hospital of Beijing University of TCM Beijing China 100078;

Dongfang Hospital of Beijing University of TCM Beijing China 100078;

Dongfang Hospital of Beijing University of TCM Beijing China 100078;

Beijing University of TCM Beijing China 100029;

Beijing University of TCM Beijing China 100029;

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The Mechanism of the combination of radix paeoniae rubra-cortex moutan in treating cerebral hemorrhage based on network pharmacology

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