目的:研究脑梗死患者M RI病灶体积与神经损害、氧化应激反应、细胞凋亡程度的相关性.方法:选择在本院诊断为脑梗死的患者作为研究对象,根据头颅M RI扫描并测定病灶体积,进而分为病灶体积≥8.5 cm3的脑梗死患者以及病灶体积<8.5 cm3的脑梗死患者;测定血清中神经损害、氧化应激反应、细胞凋亡指标的含量.结果:病灶体积≥8.5 cm3的脑梗死患者血清中GDF15、BDNF、PON1、HO-1的含量显著低于病灶体积< 8.5 cm3的脑梗死患者,GFAP、NSE、Hcy、8-O HdG、ox-LDL、HSP70、sFas、sFasL、sTRAIL、caspase-3的含量显著高于病灶体积<8.5 m3的脑梗死患者.结论:脑梗死患者M RI病灶体积增大与神经损害、氧化应激反应、细胞凋亡程度的加重有关.%Objective:To study the correlation of MRI lesion volume with nerve injury,oxidative stress response and apoptosis in patients with cerebral infarction.Methods:Patients who were diagnosed with cerebral infarction in Jingzhou First People's Hospital in Hubei Province between March 2015 and October 2017 were selected as the research subjects,and the le-sion volume was measured by the head MRI scan and then used to divide the patients with cerebral infarction into those with le-sion volume ≥8.5m3and those with lesion volume <8.5m3;the serum contents of nerve injury,oxidative stress and apoptosis indexes were measured.Results:Serum GDF15,BDNF,PON1 and HO-1 contents of cerebral infarction patients with lesion volume ≥8.5m3were significantly lower than those of cerebral infarction patients with lesion volume <8.5m3whereas GFAP, NSE,Hcy,8-OHdG,ox-LDL,HSP70,sFas,sFasL,sTRAIL and caspase-3 contents were significantly higher than those of cerebral infarction patients with lesion volume <8.5m3.Conclusion:The increase of MRI lesion volume in patients with cere-bral infarction is related to the aggravation of nerve injury,oxidative stress response and apoptosis.
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