目的:探讨冠脉CTA钙化积分(CACS)与冠心病患者血清炎性因子、斑块稳定性指标的相关性.方法:选择2014年11月~2017年3月在本院接受检查的拟诊冠心病患者228例,检测不同病变者CACS水平以及血清炎症因子、斑块稳定性指标含量的差异.采用 Pearson 检验评估冠心病患者CACS水平与病情严重程度的内在联系.结果:三支病变组患者的CACS水平高于两支病变组、单支病变组,两支病变组患者的CACS水平高于单支病变组;三支病变组患者血清中可溶性细胞间黏附分子(sICAM-1)、白介素-6(IL-6)、白介素-18(IL-18)、C反应蛋白(CRP)、五聚素3(PTX3)、脂蛋白相关磷脂酶A2(Lp-PLA2)、组织蛋白酶K(Cat K)含量高于两支病变、单支病变组;两支病变组患者血清中sI-CAM-1、IL-6、IL-18、CRP、PTX3、Lp-PLA2、Cat K 的含量高于单支病变组;三支病变组患者血清中胱抑素C(Cys C)的含量低于两支病变、单支病变组,两支病变组患者血清中Cys C含量低于单支病变组.差异均有统计学意义(P<0.05).Pearson检验发现,冠心病患者CACS水平与血清炎性因子、斑块稳定性指标含量直接相关.结论:冠心病患者随病情加剧CACS水平上升,具体CACS水平与机体炎症反应程度、斑块稳定性均直接相关.%Objective:To investigate the correlation of coronary CTA calcification score(CACS)with serum inflamma-tory factors and plaque stability-related indexes in patients with coronary heart disease.Methods:228 patients with possible cor-onary heart disease who were examined in this hospital between November 2014 and March 2017 were selected,and the CACS levels as well as the serum contents of inflammatory factors and plaque stability indexes in patients with different lesions were determined.Pearson test was used to assess the correlation between CACS level and disease severity in patients with coronary heart disease.Results:The CACS level of triple vessel disease group was higher than that of double vessel disease group and single vessel disease group,and the CACS level of double vessel disease group was higher than that of single vessel disease group;serum sICAM-1,IL-6,IL-18,CRP,PTX3,Lp-PLA2 and Cat K contents were higher than those of double vessel dis-ease group and single vessel disease group;serum sICAM-1,IL-6,IL-18,CRP,PTX3,Lp-PLA2 and Cat K contents of doub-le vessel disease group were higher than those of single vessel disease group;serum Cys C content of triple vessel disease group was lower than that of double vessel disease group and single vessel disease group,and serum Cys C content of double vessel disease group was lower than that of single vessel disease group.Pearson test showed that the CACS level in patients with coro-nary heart disease was directly correlated with serum contents of inflammatory factors and plaque stability indexes.Conclusion:The CACS levels in patients with coronary heart disease increase with the aggravation of disease,and the specific CACS level is directly correlated with the degree of inflammatory response and the stability of the plaques.
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