目的：：观察替罗非班对急性心肌梗死患者 PCI 术后肌钙蛋白、脑钠肽及心功能的影响,为更好的治疗急性心肌梗死提供科学依据.方法：将2014年6月~2016年6月余姚市人民医院收治100的急性心肌梗死患者纳入为研究对象,随机分为观察组50例和对照组50例,两组患者均接受常规 PCI 术治疗,观察组在此基础上加用替罗非班注射液,比较两组患者治疗前后的 cTnI、BNP 及超声心动图指标(LVEF、LVEDD、LVESD)的变化.结果：术前,两组患者的 cTnI 水平无统计学差异(P ＞0．05)；术后12 h、24 h,两组 cTnI 水平均较术前有所升高(P ＜0．05)；但与对照组比较,观察组术后24 h 的 cTnI 水平为(0．10±0．23)ng/mL 低于对照组的(0．24±0．31)ng/mL,差异有统计学意义(P ＜0．05).术前,两组患者的 BNP 水平无统计学差异(P ＞0．05)；术后7 d、30 d 两组 BNP 水平均显著降低,且观察组降低幅度大于对照组,BNP 水平低于对照组治疗后(P ＜0．05).术后7 d,观察组的 LVEF 显著高于对照组(P ＜0．05),而两组之间的 LVEDD、LVESD 差异无统计学意义(P ＞0．05).术后30d,观察组 LVEDD、LVESD 显著低于对照组,LVEF 仍显著高于对照组,比较均有显著性差异(P ＜0．05).结论：替罗非班对急性心肌梗死患者 PCI 术后肌钙蛋白、脑钠肽及心功能均有改善作用,在减轻心肌损伤的同时可促进心功能的恢复.%[ABSTRACT]Objective:To observe the influence of tirofiban on the troponin,brain natriuretic peptide,heart function in patients with acute myocardial infarction after PCI and provide scientific basis for treatment of acute myocardial infarction. Method:A total of 100 cases of hypertensive cerebral hemorrhage patients in our hospital were selected and randomly divided into 2 groups:the control group (50 cases)and the observation group (50 cases).The conventional treatment of PCI was per-formed on both groups.Tirofiban injection was given to the observation group on the basis of conventional treatment.cTnI, BNP and echocardiographic parameters (LVEF,LVEDD,LVESD)were detected before and after treatment.Results:The comparison of cTnI in the two groups before operation was not statistically significant (P > 0.05 ).cTnI in the 2 groups in-creased 12 h and 24 h after operation.But the cTnI in observation group (0.10±0.23)ng/mL decreased more significantly than that in control group (0.24±0.31)ng/mL (P <0.05).The comparison of BNP in the two groups before operation was not sta-tistically significant (P >0.05).BNP in the 2 groups decreased significantly 7 d and 30 d after operation;BNP in observation group decreased more significantly than that in control group (P <0.05).LVEF in the observation group increased significantly compared with that in control group 7 d after operation(P <0.05.The comparison of LVEDD,LVESD were not considered to be statistically significant(P >0.05).LVEDD and LVESD in the observation group were lower than that in control group sig-nificantly 30 d after operation,while the LVEF in the observation group was still higher than that in the control group (P <0.05).Conclusions:Tirofiban can improve the troponin,brain natriuretic peptide,heart function in patients with acute myocar-dial Infarction after PCI.It can also decrease the heart injury as well as helping the recovery of heart function.
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