[ABSTRACT]Objective:To explore the differences in the effect of peroral traction-assisted endoscopic submucosal dissec-tion (ESD)and traditional ESD for the treatment of early gastric cancer and precancerous lesions.Methods:A total of 1 12 pa-tients with early gastric cancer and precancerous lesions treated in our hospital between May 2013 and May 201 6 were collected and divided into control group and observation group according to the random number table.Observation group of patients re-ceived peroral traction-assisted ESD,and the control group of patients only received traditional ESD.The intraoperative dissec-ted lesion diameter,mean operation time and intraoperative blood loss of two groups of patients were recorded,enzyme-linked immunosorbent assay was used to detect serum inflammatory factor levels,and RIA was used to detect serum stress hormone levels.Results:Dissected lesion diameter of observation group was greater than that of control group while mean operation time and intraoperative blood loss were less than those of control group;1d after operation,serum inflammatory factors interleukin-6 (IL-6),interleukin-8 (IL-8),interleukin-12 (IL-12)and tumor necrosis factor-α(TNF-α)levels of observation group were lower than those of control group,and serum stress hormones cortisol (Cor),β-endorphin (β-EP),epinephrine (E),norepi-nephrine (NE)and angiotensin Ⅱ (ATⅡ)levels were lower than those of control group.Conclusion:Peroral traction-assisted ESD can effectively increase the lesion dissection effect and reduce the postoperative inflammatory response and stress response in patients with early gastric cancer and precancerous lesions.%目的：：探讨经口牵引辅助下内镜黏膜下剥离术(endoscopic submucosal dissection,ESD)与传统ESD 治疗早期胃癌及癌前病变的效果差异。方法：收集在本院接受治疗的早期胃癌及癌前病变患者112例,按照随机数表法分为对照组及观察组。观察组接受经口牵引辅助下 ESD 治疗,对照组仅接受传统 ESD 治疗。记录两组术中剥离病变直径、手术平均时间、术中出血量,采用酶联免疫吸附法检测血清炎症因子含量,采用放射免疫法测定血清应激激素含量。结果：观察组剥离病变直径大于对照组,手术平均时间、术中出血量少于对照组；术后1 d,观察组的血清炎症因子白介素-6(IL-6)、白介素-8(IL-8)、白介素-12(IL-12)、肿瘤坏死因子-α(TNF-α)含量低于对照组,血清应激激素皮质醇(Cor)、β-内啡肽(β-EP)、肾上腺素(E)、去甲肾上腺素(NE)、血管紧张素Ⅱ(ATⅡ)含量低于对照组。结论：经口牵引辅助下 ESD 可以有效提高早期胃癌及癌前病变患者的病灶剥离效果,减少术后炎症及应激反应。
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