[ABSTRACT]Objective:To explore the risk factors of rebleeding after endoscopic therapy in patients with non-variceal up-per gastrointestinal bleeding (NVUGIB).Methods:A total of 254 patients with NVUGIB who were admitted in our hospital for endoscopic therapy were included in the study and divided into the rebleeding group (n =76)and non-bleeding group (n =1 78) according to whether there was rebleeding or not.The general materials and laboratory examination results in the two groups were recorded.The single factor and multiple factor logistic regression analysis was used to evaluate the risk factors of rebleed-ing after endoscopic therapy in patients with NVUGIB.Results:The single factor analysis showed that the comparison of heart rate after admission > 100 times/min,upper gastrointestinal tumor bleeding,grade Ⅰ a bleeding,initial endoscopic therapy time>24 h,bleeding lesion diameter>2 cm,single endoscopic therapy method,amount of bleeding>800 mL,sequential PPIs insufficiency,and PT≥1 7 s between the two groups was statistically significant (P <0.05).The multiple factor logistic regres-sion analysis showed that grade Ⅰ a bleeding,malignant tumor bleeding,bleeding lesion diameter> 2 cm,single endoscopic therapy method,and sequential PPIs insufficiency were significantly positively correlated with the occurrence of rebleeding after endoscopic therapy in patients with NVUGIB (P <0.05).Conclusions:Grade Ⅰa bleeding,malignant tumor bleeding,bleeding lesion diameter>2 cm,sequential PPIs insufficiency,and PT≥1 7 s are the independent risk factors for developing rebleeding after endoscopic therapy in patients with NVUGIB.%目的：：探讨非静脉曲张性上消化道出血(NVUGIB)经内镜治疗术后再出血的危险因素.方法：选取于本院行内镜下治疗的 NVUGIB 患者254例,依照术后再出血与否分为再出血组76例及未出血组178例.记录两组一般资料及实验室检查结果,通过单因素分析及多因素非条件 logistic 回归分析评价 NVUGIB 内镜治疗术后再出血的危险因素.结果：单因素分析显示,两组入院心率＞100次/min、上消化道肿瘤出血、Ⅰa 级出血、开始内镜治疗时间＞24 h、出血病变直径＞2 cm、单一内镜治疗方式、出血量＞800 mL、后续质子泵抑制剂(PPIs)不足及凝血酶原时间≥17 s 等情况差异有统计学意义(P ＜0．05)；多因素 logistic 回归分析显示,Ia 级出血、恶性肿瘤出血、出血病变＞2 cm、单一内镜治疗方式及后续 PPIs 缺乏与 NVUGIB 内镜治疗止血成功后再出血的发生显著正相关(P ＜0．05).结论：Ⅰa 级出血、恶性肿瘤出血、出血病变＞2 cm、后续 PPIs 不足及凝血酶原时间≥17 s 为 NVUGIB 内镜治疗术后再出血的独立危险因素.
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