目的:探讨定量脑电图(qEEG)对新生儿缺氧缺血性脑病(HIE)预后情况的评估价值及其与血清学指标的关系.方法:收集在本院出生并接受治疗的HIE患儿76例作为观察组、同期在本院分娩的健康新生儿50例作为正常对照组.测定两组新生儿的qEEG参数值,对比两者血清中神经损伤指标、神经凋亡指标、氧化应激指标含量的差异,采用Pearson检验评估HIE患儿qEEG参数值与其病情严重程度的内在联系.结果:观察组的qEEG Fp1、Fp2、C3、C4、T3、T4、O1、O2位点功率谱值均显著低于正常对照组新生儿(P<0.05).观察组血清中NSE、NPY、S-100B、MBP的含量高于正常对照组新生儿;神经凋亡指标sFas、sFasL、Caspase-3的含量高于正常对照组新生儿,Bcl-2的含量低于正常对照组新生儿;血清中氧化应激指标AOPP、MDA的含量高于正常对照组新生儿,SOD的含量低于正常对照组新生儿(P<0.05).经Pearson检验发现,HIE患儿的qEEG Fp1、Fp2、C3、C4、T3、T4、O1、O2位点功率谱值与神经损伤指标、神经凋亡指标、氧化应激指标含量直接相关.结论:HIE患儿qEEG参数值较正常新生儿低,且其具体值与患儿病情严重程度密切相关.%Objective: To study the value of the quantitative electroencephalogram (qEEG) in the prognosis of neonatal hypoxic ischemic encephalopathy (HIE) and its relationship with serological indicators.Methods: A total of 76 children with HIE who were born and treated in our hospital between April 2013 and February 2017 were collected as observation group, and 50 healthy newborns who were born in our hospital during the same period were collected as normal control group.qEEG parameter values of two groups of children were determined, serum levels of nerve injury indexes, nerve apoptosis indexes and oxidative stress indexes were compared between the two groups, and Pearson test was used to evaluate the inner link between qEEG parameter values and disease severity in children with HIE.Results: qEEG Fp1, Fp2, C3, C4, T3, T4, O1 and O2 loci power spectrum values of observation group were significantly lower than those of normal control group (P<0.05).Serum NSE, NPY, S-100B and MBP contents in observation group were higher than those in normal control group;nerve apoptosis indexes sFas, sFasL and Caspase-3 contents were higher than those in normal control group while Bcl-2 content was lower than that in normal control group;serum oxidative stress indexes AOPP and MDA contents were higher than those in normal control group while SOD content was lower than that in normal control group (P<0.05).Pearson test showed that qEEG Fp1, Fp2, C3, C4, T3, T4, O1 and O2 loci power spectrum values in children with HIE were directly correlated with the contents of nerve injury indexes, nerve apoptosis indexes and oxidative stress indexes.Conclusion: The qEEG parameter values in children with HIE are lower than those in normal children, and the specific values are closely related to the severity of the disease.
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