Objective:To investigate the effects of alprostadil on respiratory parameters and hemodynamics of newborns with persistent pulmonary hypertension .Methods:According to random data table method ,80 newborns of pulmonary hyper-tension were randomly divided into the control group (n=40) and observation group (n=40) ,patients in the control group were given normal frequency ventilation ,on the basis of the treatment of the control group ,the observation group received al-prostadil .The changes of respiratory parameters and hemodynamics were compared between the two groups before and after treatment .Results:The levels of respiratory parameters (SaO2 ,PaO2 ,PaCO2 ) and hemodynamics (PA ,PVR ,SVR) in the two groups before treatment were not statistically significant (P>00.5) .After treatment ,The levels of SaO2 ,PaO2 in the two groups were significantly higher than those in the same group before treatment (P<00.5) ,and the observation group levels were (907.1 ± 89.2)% ,(852.7 ± 82.3) mmHg ,which were significantly higher than those in the control group after treatment (P<00.5);The levels of PaCO2 ,PA ,PVR and SVR in the two groups after treatment were significantly lower than those in the same group before treatment (P<00.5) ,and the observation group were (352.2 ± 34.6) mmHg ,(269.5 ± 37.8) mmHg , (7257.1 ± 1088.2) dyns/cm5 ,(11252.7 ± 1522.3) dyns/cm5 ,which were significantly lower than that of the control group (P<00.5) .Conclusion:Adding alprostadil based on conventional frequent ventilation thraphy can effectively improve blood pres-sure and oxygen saturation ,and improve hemodynamics of newborns with persistent pulmonary hypertension ,which has im-portant clinical value .%目的:探讨前列地尔对新生儿持续性肺动脉高压呼吸参数及血流动力学的影响.方法:80例患有肺动脉高压的新生儿依据随机数据表法分为对照组(n=40)和观察组(n=40),对照组患者接受常频通气治疗,观察组患者在对照组的基础上给予前列地尔治疗.比较治疗前后两组呼吸参数及血流动力学的变化.结果:治疗前,两组呼吸参数(SaO2、PaO2、PaCO2)、血流动力学参数(PA、PVR、SVR)水平比较,差异无统计学意义(P>00.5).治疗后,两组SaO2、PaO2水平较组内治疗前均显著升高(P<00.5),且观察组SaO2、PaO2水平显著高于治疗后对照组,差异有统计学意义(P<00.5);两组PaCO2、PA、PVR及SVR水平均显著低于本组治疗前(P<00.5),且观察组PaCO2、PA、PVR及SVR水平显著低于对照组,差异有统计学意义(P<00.5).结论:常频通气治疗的基础上加用前列地尔治疗新生儿PPHN,可有效提高患儿血氧分压和血氧饱和度,改善患儿血流动力学,具有重要临床价值.
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