Objective:To study the clinical characteristics of different computed tomography coronary angiography(CT-CA)plaque properties in patients with coronary artery disease.Methods:Patients who were diagnosed with coronary artery dis-ease in Ankang Central Hospital between February 2015 and March 2017 were selected and divided into soft plaque group, mixed plaque group and calcified plaque group according to the plaque properties judged by CTCA examination,and healthy volunteers who received physical examination in Ankang Central Hospital during the same period were selected as control group.The serum levels of material metabolism indexes,cytokines as well as collagen synthesis and degradation indexes of the four groups were measured.Results:Serum UA,Hcy,PCSK9,LDL-C,GDF-15,CXCL5,hs-CRP,RANTES,IL-6, MMP1,ST2,CysC and I-CTP levels of soft plaque group,mixed plaque group and calcified plaque group were significantly higher than those of control group,serum UA,Hcy,PCSK9,LDL-C,GDF-15,CXCL5,hs-CRP,RANTES,IL-6,MMP1, ST2,CysC and I-CTP levels of soft plaque group and mixed plaque group were significantly higher than those of calcified plaque group,and serum UA,Hcy,PCSK9,LDL-C,GDF-15,CXCL5,hs-CRP,RANTES,IL-6,MMP1,ST2,CysC and I-CTP levels of soft plaque group were significantly higher than those of mixed plaque group.Conclusion:CTCA can accurately determine the plaque properties and evaluate the disorder of material metabolism,cytokine secretion as well as collagen synthe-sis and degradation during the change of plaque properties in patients with coronary artery disease.%目的:研究冠心病患者不同冠状动脉计算机断层成像(CTCA)斑块性质的临床特征.方法:选择在安康市中心医院诊断为冠心病的患者,并根据CTCA 检查对斑块性质的判断分为软斑块组、混合斑块组、钙化斑块组,选择同期在安康市中心医院体检的健康志愿者作为对照组.测定4组受试者血清中物质代谢指标、细胞因子、胶原合成和降解指标的含量.结果:软斑块组、混合斑块组、钙化斑块组患者血清中UA、Hcy、PCSK9、LDL-C、GDF-15、CXCL5、hs-CRP、RANTES、IL-6、MMP1、ST2、CysC、I-CTP的含量显著高于对照组(P<0.05),软斑块组、混合斑块组患者血清中UA、Hcy、PCSK9、LDL-C、GDF-15、CXCL5、hs-CRP、RANTES、IL-6、MMP1、ST2、CysC、I-CTP的含量显著高于钙化斑块组(P<0.05),软斑块组患者血清中 UA、Hcy、PCSK9、LDL-C、GDF-15、CXCL5、hs-CRP、RANTES、IL-6、MMP1、ST2、CysC、I-CTP的含量显著高于混合斑块组(P<0.05).结论:CTCA能够准确判断冠心病患者的斑块性质并评估斑块性质变化过程中物质代谢、细胞因子分泌、胶原合成和降解的紊乱.
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