Plasma total homocysteine (THCY) level and other biochemical risk factors in hypertensives with and without cardiovascular events

Akande AA; Salisu OT; Omotoso ABO; Kolo PM

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Plasma total homocysteine (THCY) level and other biochemical risk factors in hypertensives with and without cardiovascular events

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Objective:The aim of this study is to assess the correlation between traditional cardiovascular risk factors and elevated plasma tHcy level in Nigerian hypertensive. Methods: Thirty-six hypertensive patients were recruited with 36 age and sex-matched controls. The age, sex and anthropometric measurements including height, weight and body mass index (BMI) were taken. Plasma total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), tri-glycerides and tHey were analyzed. The results of the two groups were compared. Results: The mean total cholesterol and LDL-C were significantly higher in the subjects than in the controls (P=0.01 and 0.03 respectively). On the other hand, means of HDL-C and triglycerides were not significantly different between the two groups (P = 0.06 and O. 68 respectively). Mean total plasma tHey was (12. 95±4.9)μmol/L in hypertensive patients when compared with (11.29±3.6)μmol/L in the controls (P =0.09), however the mean they was significantly higher in hypertensive patients who had stroke or myocardial infarction than those without these complications (one way Anova F = 3.63, P =0.04). Significant positive correlation was seen between tHcy and systolic blood pressure, diastolic blood pressure, BMI and LDL-C. Conclusion:The study suggests that elevated plasma tH-ey may predict occurrence of cardiovascular complications in hypertensive individuals.

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《海南医学院学报》 |2009年第11期|1387-13901394|共5页
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Akande AA; Salisu OT; Omotoso ABO; Kolo PM;
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Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, PMB 1459, Ilorin, Nigeria;

Department of Chemical Pathology and Immunology, University of Ilorin Teaching Hospital, PMB 1459, Ilorin, Nigeria;

Department of Medicine, University of Ilorin Teaching Hospital, PMB 1459, Ilorin, Nigeria;

Department of Medicine, University of Ilorin Teaching Hospital, PMB 1459, Ilorin, Nigeria;

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Plasma total homocysteine (THCY) level and other biochemical risk factors in hypertensives with and without cardiovascular events

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