利用荧光光谱法、紫外光谱法和粘度法研究了Se（Ⅳ）对酒石酸长春质碱与DNA相互作用的影响。研究结果表明Se（Ⅳ）的加入使酒石酸长春质碱与DNA的主要作用力由氢键或范德华力转变为静电作用力，作用模式由沟槽结合转变为静电结合。由结合常数的改变及紫外光谱实验结果判断Se（Ⅳ）对酒石酸长春质碱与DNA的结合起抑制作用。%The effect of Se(Ⅳ)on the interaction between Catharanthine Tartrate and DNA was studied by fluorescence spectrometry, UV spectroscopy and viscosity method. The results showed that the addition of Se(Ⅳ)changed the main bind-ing force of Catharanthine Tartrate and DNA from hydrogen bond and van der Waals force into electrostatic force, and the binding mode from groove binding into electrostatic binding. The change of binding constant and the UV spectroscopy re-sults showed that Se(Ⅳ)can inhibit the binding of Catharanthine Tartrate and DNA.
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