Cirrhosis is a chronic, refractory, irreversible, high mortality, refractory disease. Professor Zhao believes that the etiology and pathogenesis of liver cirrhosis is complicated , but the initial causes were damp heat and pestilence, its pathogenesis is Yin deficiency of liver and kidney, intermingled phlegm and blood stasis, activating blood circulation and dissipating phlegm. Ruangan Sini prescription was made combined with clinical manifestations and syndrome types of modern medicine, which basic therapies were clearing heat and promoting diuresis, soothing liver and strengthening spleen, softening and resolving hard mass, tonifying Qi and Yin. The clinical effect of the prescription in treating liver cirrhosis is obvious.%肝硬化为慢性、难治性、不可逆性、高死亡率、顽固性疾病.笔者认为肝硬化的病因病机复杂多样,但始动病因为湿热疫毒,病机为肝肾阴虚、痰瘀互结、本虚标实、虚实夹杂,结合现代医学临床表现及病证分型,在治疗上立足中医整体观、辨证论治,以清热利湿、疏肝健脾、活血化痰、软坚散结、益气养阴为基本大法,创制四逆软肝方治疗肝硬化,临床疗效颇著,实现了肝硬化难以逆转的"四逆".
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