目的 探讨血栓前状态(PTS)分子与冠心病血瘀证之间的相关性.方法 研究分为家系冠心病血瘀证组、家系冠心病非血瘀证组、家系非冠心病血瘀证组、家系健康人组、非家系冠心病血瘀证组、非家系健康人组6组,运用ELlSA试剂盒检测外周静脉血血浆(或血清)中血栓调节蛋白(TM)、血小板p-选择素(P-Selectin)、凝血酶原片段1、2(Fl+2)、可溶性纤维蛋白单体(SFMC)、组织型纤溶酶原激活物(tPA)、纤溶酶原激活物抑制物(PAI-1)、凝血酶-抗凝血酶Ⅲ复合物(TAT)等分子水平.结果 家系人群研究中冠心病血瘀证患者与健康人比较TM、t-PA、P-Selectin、Fl+2、TAT水平增加,SFMC、PAI-1水平无差异；冠心病血瘀证患者与冠心病非血瘀证患者比较TM、t-PA、P-Selectin、TAT、SFMC水平增加.非家系冠心病血瘀证与非家系健康人比较各PTS分子均无差异.结论 家系人群中PTS分子与冠心病血瘀证存在一定相关性,但抗凝血、促凝血等相互拮抗的分子水平变化趋势一致值得进一步探讨；非家系冠心病血瘀证与健康人比较PTS分子均无差异；且PTS分子水平在家系和非家系人群中有明显区别,这种差异是否与遗传因素有关也值得后续研究进一步探索.%Objective To probe the correlation between prethrombotic state(PTS) molecule and syndrome of blood stasis of coronary heart disease (CHD).Methods There were six groups in the study,including the syndrome of blood stasis of a CHD family group,the syndrome of non-bloodstasis of a CHD family group,the syndrome of blood stasis of non-CHD from a CHD family,healthy people from a CHD family group,the syndrome of blood stasis of a CHD of a nonCHD family group and healthy people from non-CHD family group 7 markers including throm bomodulin(TM),(P-selectin),prothrombinfragment 1+2(F1+2),soluble fibrin monomer complex(SFMC),tissue-type plasminogen activator(t-PA),plasminogen activator inhibitor-1(PAI-1) and thrombin-antithrombin complex (TAT),were detected by ELISA method.Results In a CHD family,the levels of TM,t-PA,P-selectin,F1+2 and TAT in the syndrome of blood stasis of CHD group were higher than those of healthy people while the levels of SFMC and PAI-1 had no significant differences between the two groups.More,the level of TM,t-PA,P-selectin,TAT and SFMC in the syndrome of blood stasis of a CHD family group were higher than those in the syndrome of nonblood-stasis of a CHD family group.However,there were no differences of these PTS markers between the syndrome of blood stasis of a non-CHD family group and healthy people from non-CHD family group.Conclusion In a CHD family groups,there are relationship between PTS markers and the syndrome of blood stasis of CHD.However,the anticoagulation markers and coagulation markers show the same variation trend,which needs further study.More,the PTS markers have obvious differences between CHD family group and non-CHD family group.Further study should be done about whether the differences in PTS markers are related with the genetic factor.
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