Objective To investigate the effects of Liuwei Dihuang pills on adipocyte in normal rats. Methods 75 SD male rats were divided randomly into three groups normal group, control group and Liuwei Dihuang pills group, 25 rats in each group. 10 mice in each group at 4th and 8th week were random respectively to be anaesthesia and measured for abdominal circumference and observed adipose tissues with cytomorphology. Results The pills increased significantly the fat content in abdominal cavity, decreased the number but increased the area of fatty cells in the visual field, the differences between Liuwei Dihuang pills group other two groups were significant (P < 0.05 and P < 0.01). Conclusion Liuwei Dihuang pills can increase the weight, fat content and enlarged the area of fatty cell to cause obesity. ,%目的 探讨六味地黄丸对正常大鼠脂肪细胞生长的影响.方法 将75只雄性SD大鼠,随机分成3组,即普通饲料组(正常组)、高脂饲料组(对照组)、六味地黄丸组(实验组),每组25只.分别于实验的第4周和第8周从每组中随机取10只大鼠进行麻醉,测量腹围,取脂肪组织等处理,将脂肪组织作细胞形态学观察.结果 六味地黄丸能显著增加大鼠腹腔脂肪含量,减少单位视野所见的脂肪细胞个数,增加单位视野中脂肪细胞的面积,与正常组及对照组比较,差异有统计学意义(P＜ 0.05,P＜0.01).结论 六味地黄丸能使大鼠体质量指数增大、脂肪含量增多、脂肪细胞面积增大,可引起肥胖.
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