导电聚合物具有良好的导电性能,可以作为分子导线使电子在生物活性物质与电极间直接传递,是构建生物传感器的一种新型材料.聚吡咯(PPy)具有导电性、生物相容性、易固定等特点,在传感器中用于固定生物活性物质有着良好的应用前景.该文简要介绍了导电聚吡咯的合成方法及掺杂机理,重点评述了聚吡咯用于固定生物活性物质构建生物传感器的多种方法及其优缺点,特别介绍了其在免疫传感器领域的最新应用,并展望了聚吡咯生物传感器的发展前景.%Conducting polymer could be used as molecular wires for transferring electrons directly between bioactive materials and electrode materials for its good conductivity, and is considered to be a new type of material for fabrication of biological sensors. With some excellent features such as electrical conductivity, biocompatibility and easy immobilization, polypyrrole ( PPy ) has a good application prospect in the immobilization of bioactive components in sensors. In this paper, the latest research development on biosensors based on PPy is reviewed. The synthesis methods of PPy together with its doping mechanisms were firstly introduced. The various methods for the immobilization of biocompo-nents on PPy and the fabrications of biosensors based on PPy were described in detail, together with the advantages and disadvantages of the immobilization methods of biocomponents to PPy. Especially, the latest applications of PPy in the field of immunosensors were reviewed. The development direction of conducting PPy biosensors in the future was also put forword.
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