Effects of low ambient temperatures and dietary vitamin C supplementation on pulmonary vascular remodeling and hypoxic gene expression of 21-d-old broilers

ZENG Qiu-feng; YANG Xia; ZHENG Ping; ZHANG Ke-ying; LUO Yu-heng; DING Xue-mei; BAI Shi-ping

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Effects of low ambient temperatures and dietary vitamin C supplementation on pulmonary vascular remodeling and hypoxic gene expression of 21-d-old broilers

机译：低温和饮食中补充维生素C对21日龄肉仔鸡肺血管重构和缺氧基因表达的影响

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The objective of this study was to evaluate the effects of low ambient temperature(LAT) and dietary vitamin C(VC)supplementation on pulmonary vascular remodeling(PVR) and the relative expression of hypoxia inducible factor-1α(HIF-1α),vascular endothelial growth factor(VEGF) and its receptor 2(VEGFR-2) mRNA of lungs in 21-d-old broilers.4001-d-old male Cobb broilers were assigned randomly to 4 treatments as follows for 21 d:1) LAT and a basal diet;2) LAT and a basal diet supplemented with 1 000 mg kg^(-1) VC(LAT+VC);3) normal ambient temperature(NAT) and a basal diet;4) NAT and a basal diet supplemented with 1 000 mg kg^(-1) VC(NAT+VC).Each treatment was composed of 10 replicates of 10 birds per replicate.Samples of lung were collected after the broilers were killed at d 21.LAT increased the ratio of vessel wall area to vessel total area(WA/TA,%) and mean media thickness in pulmonary arterioles(mMTPA,%)(P<0.05).Dietary VC supplementation decreased mMTPA(P<0.05),but had no effect on the WA/TA.LAT increased(P<0.05) the relative mRNA expression of HIF-1α,VEGF and VEGFR-2,while adding VC to the diet could decrease(P<0.05) their relative mRNA expression.A significant positive correlation existed between the level of VEGF mRNA expression and the value of WA/WT(P<0.05) or mMTPA(P<0.05).These results suggested LAT resulted in pulmonary vascular remodeling,and the increase of HIF-1a,VEGF and VEGFR-2 mRNA expression,and dietary VC supplementation can alleviate pulmonary vascular remodeling in broiler by affecting these gene expression.

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《农业科学学报（英文版）》 |2016年第1期|183-190|共8页
作者
ZENG Qiu-feng; YANG Xia; ZHENG Ping; ZHANG Ke-ying; LUO Yu-heng; DING Xue-mei; BAI Shi-ping;
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作者单位

Key Laboratory for Animal Disease Resistance Nutrition, Ministry of Education/Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, P.R.China;

Key Laboratory for Animal Disease Resistance Nutrition, Ministry of Education/Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, P.R.China;

Key Laboratory for Animal Disease Resistance Nutrition, Ministry of Education/Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, P.R.China;

Key Laboratory for Animal Disease Resistance Nutrition, Ministry of Education/Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, P.R.China;

Key Laboratory for Animal Disease Resistance Nutrition, Ministry of Education/Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, P.R.China;

Key Laboratory for Animal Disease Resistance Nutrition, Ministry of Education/Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, P.R.China;

Key Laboratory for Animal Disease Resistance Nutrition, Ministry of Education/Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an 625014, P.R.China;

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收录信息中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
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正文语种 eng
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Effects of low ambient temperatures and dietary vitamin C supplementation on pulmonary vascular remodeling and hypoxic gene expression of 21-d-old broilers

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