Effects of two eflfux pump inhibitors on the drug susceptibility of Riemerella anatipestiferisolates from China

LI Ya-fei; JIANG Hong-xia; XIANG Rong; SUN Na; ZHANG Ya-nan; ZHAO Li-qing; GU Peng; WANG Li-qiao; ZENG Zhen-ling

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Effects of two eflfux pump inhibitors on the drug susceptibility of Riemerella anatipestiferisolates from China

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The objective of this study was to verify the supposition that eflfux might be involved in the drug resistance ofRiemerela anatipestiferisolates. Two broad-spectrum eflfux pump inhibitors, carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and Phe-Arg-β-naphthylamide (PAβN), on the contribution of minimum inhibitory concentrations of amikacin, streptomycin, chloramphenicol, tetracycline, ceftriaxone, ceftazidime, nalidixic acid, levolfoxacin, enrolfoxacin, as wel as ciprolfoxacin against 69 clinicalR. anatipestiferisolates were investigated. We ifrst reported that the two eflfux pump inhibitors could restore the antimicrobial susceptibility ofR. anatipestifer isolates. It is suggested that active eflfux system is possible to be linked with the development of resistance inR. anatipestifer isolates.

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《农业科学学报（英文版）》 |2016年第4期|929-933|共5页
作者
LI Ya-fei; JIANG Hong-xia; XIANG Rong; SUN Na; ZHANG Ya-nan; ZHAO Li-qing; GU Peng; WANG Li-qiao; ZENG Zhen-ling;
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Laboratory of Veterinary Pharmacology, Colege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.China;

Laboratory of Veterinary Pharmacology, Colege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.China;

Institute of Animal Healthy, Guangdong Academy of Agricultural Sciences/Guangdong 0pen Laboratory of Veterinary Public Health, Guangzhou 510640, P.R.China;

Institute of Special Animal and Plant Sciences, Chinese Academic of Agricultural Sciences, Changchun 130112, P.R.China;

Laboratory of Veterinary Pharmacology, Colege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.China;

Laboratory of Veterinary Pharmacology, Colege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.China;

Laboratory of Veterinary Pharmacology, Colege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.China;

Laboratory of Veterinary Pharmacology, Colege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.China;

Laboratory of Veterinary Pharmacology, Colege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P.R.China;

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Effects of two eflfux pump inhibitors on the drug susceptibility of Riemerella anatipestiferisolates from China

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