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首页> 中文期刊> 《农业科学学报（英文版）》 >Genetic characterization of antimicrobial resistance in Staphylococcus aureus isolated from bovine mastitis cases in Northwest China

Genetic characterization of antimicrobial resistance in Staphylococcus aureus isolated from bovine mastitis cases in Northwest China

         
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摘要

Staphylococcus aureus is the most common etiological pathogen of bovine mastitis. The resistant strains make the disease difficult to cure. The aim of this study was to characterize the genetic nature of the antimicrobial resistance in S. aureus cultured from bovine mastitis in Northwest China in 2014. A total of 44 S. aureus were isolated for antimicrobial resistance and resistance-related genes. Antimicrobial resistance was determined by disc diffusion and the corresponding resistance genes were detected by PCR. Phenotype indicated that S. aureus isolates were resistant to penicillin(84.09%), erythromycin(20.45%), tetracycline(15.91%), gentamicin(9.09%), tobramycin(6.82%), kanamycin(6.82%) and methicillin(2.27%). 9.09% of the S. aureus isolates were classified as multidrug resistant. In addition, genotypes showed that the isolates were resistant to rifampicin(100%, rpo B), penicillin(95.45%, bla Z), tetracycline(22.73%, tet K, tet M, alone or in combination), erythromycin(22.73%, erm B or erm C), gentamicin/tobramycin/kanamycin(2.27%, aac A-aph D), methicillin(2.27%, mec A) and vancomycin(2.27%, van A). Resistance to tetracycline was attributed to the genes tet K and tet M(r=0.558, P <0.001). This study noted high-level geno- and phenotypic antimicrobial resistance in S. aureus isolates from bovine mastitis cases in Northwest China.

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  • 来源
    《农业科学学报（英文版）》 |2016年第12期|2842-2847|共6页
  • 作者

    YANG Feng; WANG Qi; WANG Xu-rong; WANG Ling; LI Xin-pu; LUO Jin-yin; ZHANG Shi-dong;

  • 作者单位

    Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture/Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province/Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R.China;

    State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R.China;

    Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture/Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province/Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R.China;

    Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture/Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province/Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R.China;

    Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture/Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province/Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R.China;

    Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture/Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province/Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R.China;

    Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture/Engineering & Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province/Lanzhou Institute of Husbandry and Pharmaceutical Sciences,Chinese Academy of Agricultural Sciences, Lanzhou 730050, P.R.China;

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